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VANCOUVER, BRITISH COLUMBIA / ACCESS Newswire / December 31, 2025 / CoTec Holdings Corp. (TSXV:CTH,OTC:CTHCF)(OTCQB:CTHCF) (‘CoTec’ or the ‘Company’) is pleased to note MagIron LLC’s (‘MagIron’) press release dated December 31, 2025, following its prior press release dated December 19, 2025. CoTec owns 16.5% of the equity in MagIron on a fully diluted basis.

MagIron announced that it has successfully completed the acquisition of the pellet plant located near Reynolds, Indiana (‘Reynolds Pellet Plant’) from the Receivership Estate of Altos Hornos De Mexico, S.A.B De C.V. (the ‘Acquisition’) on schedule and in accordance with the Asset Purchase Agreement (‘APA’).

Larry Lehtinen, CEO of MagIron commented: ‘The completion of this transaction marks a significant milestone for MagIron. We now look forward to implementing our restart strategy and bringing significant investment and job creation to both Minnesota and Indiana.’

Julian Treger, CoTec CEO commented: ‘The Reynolds Pellet Plant is a modern straight grate, past producing, restart-ready pelletizer benefitting from approximately $440 million of prior investment. The completion of its acquisition enables MagIron to now focus on the execution of its strategy to become a fully integrated DR pellet producer to America’s fast growing Electric Arc Furnace steel industry and pursuing the development of merchant pig iron facilities. CoTec is very supportive of this strategy and believes that, if successful, MagIron could become a significant contributor to the USA steel industry.’

For more information on this press release, please visit https://magironusa.com

About CoTec

CoTec Holdings Corp. (TSX-V:CTH)(OTCQB:CTHCF) is redefining the future of resource extraction and recycling. Focused on rare earth magnets and strategic materials, CoTec integrates breakthrough technologies with strategic assets to unlock secure, sustainable, and low-cost supply chains for the United States and its allies.

CoTec’s mission is clear: accelerate the energy transition while strengthening U.S. economic and national security. By investing in and deploying disruptive technologies, the Company delivers capital-efficient, scalable solutions that transform marginal assets, tailings, waste streams, and recycled products into high-value critical minerals.

From its HyProMag USA magnet recycling joint venture in Texas, to iron tailings reprocessing in Québec, to next-generation copper and iron solutions backed by global majors, CoTec is building a diversified portfolio with long-term growth, rapid cash flow potential, and high barriers to entry. The result is a game-changing platform at the intersection of technology, sustainability, and strategic materials.

For more information, please visit www.cotec.ca

For further information, please contact:

Braam Jonker – (604) 992-5600
Chief Financial Officer

Forward-Looking Information Cautionary Statement

Statements in this press release regarding the Company and its investments which are not historical facts are ‘forward-looking statements’ which involve risks and uncertainties, including statements relating to the Company’s interest in MagIron, the completion of the Acquisition, the potential restart of the MagIron operations, the MagIron strategy, including a potential development of pig iron facilities and management’s expectations with respect to its current and potential future investments, and the benefits to the Company which may be implied from such statements. Since forward-looking statements address future events and conditions, by their very nature, they involve inherent risks and uncertainties. Actual results in each case could differ materially from those currently anticipated in such statements, due to known and unknown risks and uncertainties affecting the Company, including but not limited to resource and reserve risks; environmental risks and costs; labor costs and shortages; uncertain supply and price fluctuations in materials; increases in energy costs; labor disputes and work stoppages; leasing costs and the availability of equipment; heavy equipment demand and availability; contractor and subcontractor performance issues; worksite safety issues; project delays and cost overruns; extreme weather conditions; and social and transport disruptions. For further details regarding risks and uncertainties facing the Company please refer to ‘Risk Factors’ in the Company’s filing statement dated April 6, 2022, a copy of which may be found under the Company’s SEDAR profile at www.sedar.com. The Company assumes no responsibility to update forward-looking statements in this press release except as required by law. Readers should not place undue reliance on the forward-looking statements and information contained in this news release and are encouraged to read the Company’s continuous disclosure documents which are available on SEDAR at www.sedarplus.ca.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this news release.

SOURCE: CoTec Holdings Corp.

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Here’s a quick recap of the crypto landscape for Monday (December 29) as of 9:00 p.m. UTC.

Get the latest insights on Bitcoin, Ether and altcoins, along with a round-up of key cryptocurrency market news.

Bitcoin and Ether price update

Bitcoin (BTC) was priced at US$87,107.03, down by 0.4 percent over 24 hours.

Bitcoin price performance, December 29, 2025.

Bitcoin price performance, December 29, 2025.

Chart via TradingView.

BTC’s spot market shows mild selling pressure with a slight price decline, neutral momentum from the RSI at 45.40 and a low positive funding rate of 0.008 percent, suggesting limited bullish aggression in derivatives.

Mostly long liquidations totaling US$1.67 million over four hours leading up to the end of the trading day, alongside a 0.35 percent drop in open interest to US$57.54 billion, point to deleveraging among overextended buyers, while thin holiday trading volumes amplify small moves.

The data signals continued consolidation, holding the key support around US$86,000, despite a weekly dip. Overall, traders appear sidelined with bearish short-term momentum.

Linh Tran, a senior market Analyst at XS.com, suggests that BTC is entering a phase of stability and renewed accumulation in Q1 2026, rather than a strong growth phase at the beginning of the year.

“However, recent data also indicate that ETF flows are no longer consistently strongly net positive as in the early phase of the cycle, but have become more volatile, with some weeks even recording net outflows amid portfolio rebalancing and holiday-related liquidity conditions.

In my view, this does not imply that Bitcoin’s long-term trend has turned bearish, but rather suggests that institutional demand in Q1 2026 is likely to be more selective and cautious, instead of acting as a catalyst for a sharp breakout in Bitcoin prices.”

Regulatory progress, BTC’s correlation as a risk asset to the US equity market, and geopolitical risks will also act as catalysts.

“Bitcoin’s underlying structure is significantly more solid than in previous cycles, thanks to institutional participation and broader acceptance within the financial system. If institutional flows return, the regulatory and geopolitical environment becomes more supportive, and the Fed’s policy stance begins to signal that rate cuts are approaching earlier in the year, this combination could create an ideal environment for Bitcoin to recover and reclaim the US$100,000 level.”

Ether (ETH) was priced at US$$2,928.18, down by 0.1 percent over the last 24 hours.

Altcoin price update

  • XRP (XRP) was priced at US$1.85, down by 0.7 percent over 24 hours.
  • Solana (SOL) was trading at US$122.97, down by 0.3 percent over 24 hours.

Today’s crypto news to know

Strategy announces latest BTC purchase

Strategy (NASDAQ:MSTR) announced its latest BTC purchase of 2025, adding 1,229 BTC between December 22-28 for a purchase price of US$108.8 million, according to a Form 8-K filed on Monday.

The purchase brings Strategy’s total Bitcoin holdings to 672,497 BTC.

Chinese banks to pay interest on digital yuan wallets from January 2026

China’s central bank, the People’s Bank of China (PBOC), is updating its digital yuan (e-CNY) rules effective January 1, 2026, to let commercial banks pay interest on users’ wallet balances, according to a PBOC-affiliated China Financial Times article published on Monday. This shifts the e-CNY from just a digital cash replacement to something more like a bank deposit, aiming to boost everyday use after years of slow adoption.

PBOC deputy governor Lu Lei explained the changes in the article: ‘Looking ahead, the choice of business and technology models for the digital yuan will adhere to the fundamental principle of meeting the needs of the real economy. It will adopt a principle of inclusiveness and prudent selection regarding the development of account-based and value-based digital currencies, and promote the digital yuan to meet the needs of different scenarios and different business entities.’

ALT5 Sigma’s auditor switch draws regulatory heat

Nasdaq-listed crypto firm ALT5 Sigma (NASDAQ:ALTS) is under renewed scrutiny after it emerged that its newly appointed auditor is currently barred from conducting audits due to an inactive firm license.

According to the Financial Times, the issue surfaced after the company missed its third-quarter filing deadline and hastily replaced its previous auditor earlier this month.

The new firm, Victor Mokuolu CPA PLLC, does not hold an active Texas firm license, effectively preventing it from issuing any audit opinions under state rules.

While the firm’s founder renewed his personal CPA license in late August, state records show the firm itself remains unlicensed as of late December. ALT5 Sigma told the Financial Times that no reviews or audits will be issued until the licensing issue is resolved, with a mandatory peer review now underway and expected to conclude by the end of January.

Russia floats Bitcoin mining at occupied Ukrainian nuclear plant

Officials at the Russia-controlled Zaporizhzhia nuclear power plant say they are prepared to supply electricity to Bitcoin miners, but only if a broader peace deal involving Ukraine is reached.

The plant, seized by Russian forces in March 2022 and now operated by state-owned Rosenergoatom, could power crypto mining farms alongside civilian infrastructure, representatives told Russian media.

The comments followed remarks by President Vladimir Putin that US-Russia discussions have expanded beyond security to include economic proposals tied to the facility’s output. Putin said American counterparts had expressed interest in using the plant’s electricity both for cryptocurrency mining and for supplying power to Ukraine.

XRP and Solana defy crypto fund outflows, Bitcoin and Ether slide

Crypto investment products bled US$446 million in net outflows last week, extending the sector’s post-October slump and pushing cumulative withdrawals since the sharp market downturn to US$3.2 billion.

According to the recent Digital Asset Fund Flows Weekly report by CoinShares, Bitcoin and Ethereum bore the brunt of the selling. In contrast, XRP and Solana stood out as rare bright spots, pulling in US$70.2 million and US$7.5 million in weekly inflows, respectively.

By late December, XRP ETFs had logged more than US$1 billion in cumulative inflows, while Solana ETFs had surpassed US$750 million.

Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.

Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

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TORONTO, ON / ACCESS Newswire / December 31, 2025 / NextSource Materials Inc. (TSX:NEXT,OTC:NSRCF)(OTCQB:NSRCF) (‘NextSource’ or the ‘Company’) is pleased to announce the results of the Annual Meeting of Shareholders of the Company (the ‘Meeting’) held virtually at 8:00 AM (Toronto time) on December 30, 2025.

AGM Results

The final voting results of the Meeting are set out below:

  1. Election of Directors. The Company’s shareholders elected each of the nominees as directors to serve until the next annual meeting of shareholders, or until their respective successors are elected or appointed. The following table sets forth the voting results with respect to the election of directors:

Nominee

For

Against

Sir Mick Davis

99.6%

0.4%

Hanré Rossouw

99.5%

0.5%

Christopher Kruba

99.7%

0.3%

Ian Pearce

99.7%

0.3%

Craig Scherba

99.5%

0.5%

Brett Whalen

99.5%

0.5%

2. Appointment of Auditor. The Company’s shareholders approved the appointment of PricewaterhouseCoopers LLP, Chartered Professional Accountants, as the Company’s auditors for the fiscal year ending June 30, 2026 and that the Board of Directors is authorized to fix their remuneration. The following table sets forth the voting results with respect to the appointment of PricewaterhouseCoopers LLP:

For

Withheld

99.9%

0.1%

A total of 101,161,308 common shares equivalent to 54.7% of the common shares entitled to vote were represented in person or by proxy at the Meeting.

ABOUT NextSource Materials Inc.

NextSource Materials Inc. is a battery materials company based in Toronto, Canada that is intent on becoming a vertically integrated global supplier of battery materials through the mining and value-added processing of graphite and other minerals.

The Company’s Molo graphite project in Madagascar is one of the largest known and highest-quality graphite resources globally, and the only one with SuperFlake® graphite. The Molo mine has begun production through Phase 1 mine operations.

The Company is also developing a significant downstream graphite value-add business through the staged rollout of Battery Anode Facilities (BAF) capable of large-scale production of coated, spheronized and purified graphite for direct delivery to battery and automotive customers, in a fully transparent and traceable manner. The Company is now in the process of developing its first BAF in the UAE.

NextSource Materials is listed on the Toronto Stock Exchange under the symbol ‘NEXT’ and on the OTCQB under the symbol ‘NSRCF’.

For further information about NextSource Materials, please visit our website at www.nextsourcematerials.com or contact us at +1.416.364.4911 or email Brent Nykoliation, Executive Vice President at brent@nextsourcematerials.com.

CAUTIONARY NOTE

This press release contains statements that may constitute ‘forward-looking information’ or ‘forward-looking statements’ within the meaning of applicable Canadian and United States securities legislation. Readers are cautioned not to place undue reliance on forward-looking information or statements. Forward looking statements and information are frequently characterized by words such as ‘plan’, ‘expect’, ‘project’, ‘intend’, ‘believe’, ‘anticipate’, ‘estimate’, ‘potential’, ‘possible’ and other similar words, or statements that certain events or conditions ‘may’, ‘will’, ‘could’, or ‘should’ occur. Forward- looking statements include any statements regarding, among others, reaching nameplate production capacity and the rollout of Battery Anode Facilities including the capabilities and the timing and economics thereof. These statements are based on current expectations, estimates and assumptions that involve a number of risks, which could cause actual results to vary and, in some instances, to differ materially from those anticipated by the Company and described in the forward-looking statements contained in this press release. No assurance can be given that any of the events anticipated by the forward-looking statements will transpire or occur or, if any of them do so, what benefits the Company will derive there from. The forward-looking statements contained in this news release are made as at the date of this news release and the Company does not undertake any obligation to update publicly or to revise any of the forward-looking statements, whether because of new information, future events or otherwise, except as may be required by applicable securities laws. Although the forward-looking statements contained in this news release are based on what management believes are reasonable assumptions, the Company cannot assure investors that actual results will be consistent with them. These forward-looking statements are made as of the date of this news release and are expressly qualified in their entirety by this cautionary statement. Subject to applicable securities laws, the Company does not assume any obligation to update or revise the forward-looking statements contained herein to reflect events or circumstances occurring after the date of this news release.

SOURCE: NextSource Materials Inc.

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Sankamap Metals Inc. (CSE: SCU) (‘Sankamap’ or the ‘Company’) the Company and its auditor continue to work diligently toward the completion and filing of the Company’s annual audited financial statements and management’s discussion and analysis for the fiscal year ended June 30, 2025 (the ‘Required Filings’). The Company has applied to the Alberta Securities Commission for an extension of the Management Cease Trade Order (‘MCTO’), however, there can be no assurance that a further extension will be granted. The additional delay in completing the Required Filings is primarily due to the auditor awaiting the receipt of certain required information from government authorities in Solomon Islands, as well as timing constraints associated with the holiday period. The Company estimates that approximately 90% of the audit work has been completed.

The Required Filings were due to be filed by October 28, 2025. In connection with the anticipated delays in making the Required Filings, the Company made an application for a Management Cease Trade Order (‘MCTO‘) under National Policy 12-203 Management Cease Trade Orders (‘NP 12-203‘) to the Alberta Securities Commission, as principal regulator for the Company, and the MCTO was issued on October 29, 2025. The MCTO restricts all trading by the Company’s CEO and CFO in securities of the Company, whether direct or indirect. The MCTO does not affect the ability of persons who are not directors, officers or insiders of the Company to trade their securities. The MCTO will remain in effect until the Required Filings are filed or until it is revoked or varied.

The Company expects to proceed with the filing of its interim first-quarter financial statements shortly after the Required Filings have been completed and submitted.

The Company confirms that it intends to satisfy the provisions of the alternative information guidelines described in NP 12-203 by issuing bi-weekly default status reports in the form of a news release until it meets the Required Filings requirement. The Company has not taken any steps towards any insolvency proceeding and the Company has no material information relating to its affairs that has not been generally disclosed.

For further information with respect to the MCTO, please refer to the Company’s news releases dated October 21, 2025, November 4, 2025, November 18, 2025, December 3, 2025 and December 17, 2025, available for viewing on the Company’s SEDAR+ profile at www.sedarplus.ca.

About Sankamap Metals Inc.

Sankamap Metals Inc. (CSE: SCU) is a Canadian mineral exploration company dedicated to the discovery and development of high-grade copper and gold deposits through its flagship Oceania Project, located in the South Pacific. The Company’s fully permitted assets are strategically positioned in the Solomon Islands, along a prolific geological trend that hosts major copper-gold deposits; including Newcrest’s Lihir Mine, with a resource of 71.9 million ounces of gold¹ (310 Mt containing 23 Moz Au at 2.3 g/t P+P, 520 Mt containing 39 Moz Au at 2.3 g/t indicated, 81 Mt containing 5 Moz Au at 1.9 g/t measured, 61 Mt containing 4.9 Moz Au at 2.3 g/t Inferred).

Exploration is actively advancing at both the Kuma and Fauro properties, part of Sankamap’s Oceania Project in the Solomon Islands. Historical work has already highlighted the mineral potential of both sites, which lie along a highly prospective copper and gold-bearing trend, suggesting the possibility of further, yet-to-be-discovered deposits.

At Kuma, the property is believed to host an underexplored and largely untested porphyry copper-gold (Cu-Au) system. Historical rock chip sampling has returned consistently elevated gold values above 0.5 g/t Au, including a standout sample assaying 11.7% Cu and 13.5 g/t Au2; underscoring the area’s significant potential.

At Fauro, particularly at the Meriguna Target, historical trenching has returned highly encouraging results, including 8.0 meters at 27.95 g/t Au and 14.0 meters at 8.94 g/t Au3. Complementing these results are exceptional grab sample assays, including historical values of up to 173 g/t Au3, along with recent sampling by Sankamap at the Kiovakase Target, which returned numerous high-grade copper values, reaching up to 4.09% Cu. In addition, limited historical shallow drilling intersected 35.0 meters at 2.08 g/t Au3, further underscoring the property’s strong mineral potential and the merit for continued exploration. With a commitment to systematic exploration and a team of experienced professionals, Sankamap aims to unlock the untapped potential of underexplored regions and create substantial value for its shareholders. For more information, please refer to SEDAR+ (www.sedarplus.ca), under Sankamap’s profile.

1.Newcrest Technical Report, 2020 (Lihir: 310 Mt containing 23 Moz Au at 2.3 g/t P+P, 520 Mt containing 39 Moz Au at 2.3 g/t indicated, 81 Mt containing 5 Moz Au at 1.9 g/t measured, 61 Mt containing 4.9 Moz Au at 2.3 g/t Inferred)

2. Historical grab, soil and BLEG samples from SolGold Kuma Review June 2015, and SolGold plc Annual Report 2013/2012

3. September 2010-June 2012 press releases from Solomon Gold Ltd. and SolGold Fauro Island Summary Technical Info 2012

QP Disclosure

The technical content for the Oceania Project in this news release has been reviewed and approved by John Florek, M.Sc., P.Geol., a Qualified Person in accordance with CIM guidelines. Mr. John Florek is in good standing with the Professional Geoscientists of Ontario (Member ID:1228) and a director and officer of the Company.

ON BEHALF OF THE BOARD OF DIRECTORS

s/ ‘John Florek’
John Florek, M.Sc., P.Geol
Chief Executive Officer
Sankamap Metals Inc.

Contact:
John Florek, CEO
T: (807) 228-3531
E: johnf@sankamap.com

The Canadian Securities Exchange has not approved nor disapproved this press release.

Forward-Looking Statements

Certain statements made and information contained herein may constitute ‘forward-looking information’ and ‘forward-looking statements’ within the meaning of applicable Canadian and United States securities legislation. These statements and information are based on facts currently available to Sankamap and there is no assurance that the actual results will meet management’s expectations. Forward-looking statements and information may be identified by such terms as ‘anticipates,’ ‘believes,’ ‘targets,’ ‘estimates,’ ‘plans,’ ‘expects,’ ‘may,’ ‘will,’ ‘could’ or ‘would.’

This press release contains forward-looking statements, including, but not limited to, statements regarding management’s expectations about obtaining the MCTO and completing the Required Filings within the anticipated timeline. Forward-looking statements are subject to various risks, uncertainties, and other factors that could cause actual results or events to differ materially from those expressed or implied by such statements. Sankamap does not undertake any obligation to update forward-looking statements or information, except as required by applicable securities laws. For more information on the Company, investors should review the Company’s continuous disclosure filings that are available at www.sedarplus.ca.

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The NASDAQ Biotechnology Index (INDEXNASDAQ:NBI) is trading at three year highs despite market volatility, responding to breakthrough innovations and increased deals involving NASDAQ biotech stocks.

After dropping to a low of 3,637.05 in October 2023, the index climbed to a nearly three year peak of 4,954.813 on September 19, 2024. While the index pulled back to 4,530.69 in August 2025, it staged a robust recovery in the second half of the year, closing at 5,766.59 on December 29, 2025, a gain of approximately 34 percent for the year.

The top NASDAQ biotech stocks have seen sizeable share price increases over the past year. For those interested in investing in biotech companies, the best-performing small-cap biotech stocks are outlined below.

Data was gathered on December 29, 2025, using TradingView’s stock screener. Small-cap biotech stocks with market caps between US$50 million and US$500 million at that time were considered for this list.

1. SELLAS Life Sciences Group (NASDAQ:SLS)

Year-to-date gain: 210.19 percent
Market cap: US$477.18 million
Share price: US$3.35

SELLAS Life Sciences Group is a late-stage biopharmaceutical company focused on novel cancer immunotherapies. The company’s approach involves ‘teaching’ the immune system to recognize and kill cancer cells by targeting specific proteins that are overexpressed in tumors.

Its flagship asset is galinpepimut-S (GPS), a vaccine-like immunotherapy for patients with acute myeloid leukemia (AML) who are in remission but at high risk of relapse. Its secondary asset, SLS009, is a highly selective CDK9 inhibitor currently showing promise in Phase 2 trials for various blood cancers.

The company’s stock price surged on December 29 after SELLAS shared an update on the Phase 3 REGAL trial evaluating GPS as a maintenance therapy in patients with AML. The trial is designed as a blind survival study, with the end point triggered on the 80th patient death.

In the update, the company reported that 72 deaths had occurred as of December 26. Because it is taking longer than expected for the trial to complete, which was previously anticipated to happen before the end of 2025, investors are speculating that the patients in the trial are living significantly longer than the historical average.

2. IO Biotech (NASDAQ:IOBT)

Year-to-date gain: 129.47 percent
Market cap: US$144.28 million
Share price: US$2.16

IO Biotech is developing immune-modulating therapeutic cancer vaccines based on its T-win technology platform, designed to activate T cells to target both tumor cells and the immune-suppressive cells.

The clinical-stage biopharmaceutical company’s lead cancer vaccine candidate is IO102-IO103, which has the brand name Cylembio. IO102-IO103 has breakthrough therapy designation from the US Food and Drug Administration (FDA) when used in combination with Merck’s (NYSE:MRK) anti-PD-1 therapy Keytruda for the treatment of advanced melanoma based on positive Phase 1/2 first line metastatic melanoma data.

The candidate reached a major milestone in August 2025 with the readout of its pivotal Phase 3 trial of IO102-IO103 with Keytruda for treating advanced melanoma. While the vaccine combined with Keytruda showed a significant survival benefit — reaching 19.4 months of progression-free survival compared to 11 months for Keytruda alone — it narrowly missed the strict statistical significance threshold.

Following a December meeting with the FDA to discuss a path forward for Cylembio, IO Biotech ended the year focused on a new registrational trial to address the Phase 3 miss and securing further funding to extend its operations into 2026.

Throughout 2025, the company continued to expand its pipeline. In November, it presented new pre-clinical data for IO112 targeting arginase 1 and for IO170 targeting transforming growth factor.

3. Tiziana Life Sciences (NASDAQ:TLSA)

Year-to-date gain: 124.64 percent
Market cap: US$184.22 million
Share price: US$1.55

Tiziana Life Sciences is a clinical-stage biopharma which is developing therapies for autoimmune and inflammatory diseases, degenerative diseases and cancer-related to the liver. Its pipeline of candidates is built on its patented drug delivery technology that provides a possible alternative to intravenous delivery.

Tiziana’s lead candidate is intranasal foralumab, a fully human anti-CD3 monoclonal antibody, which it is currently studying for treatment of a range of conditions.

In March, the company filed an investigational new drug application with the FDA for a Phase 2 clinical trial in amyotrophic lateral sclerosis (ALS), which is supported by the ALS Association. The Phase 2 trial is slated to begin in January 2026. Tiziana also began dosing patients in a Phase 2a trial for multiple system atrophy in August.

In April, John Hopkins University and the University of Massachusetts commenced dosing of the biotech company’s intranasal foralumab in Phase 2 trials for patients with non-active secondary progressive multiple sclerosis (MS). On May 7, the company shared positive results from the use of its lead candidate in improving the quality of life for patients with that form of MS.

Tiziana is also studying the use of intranasal foralumab for treating moderate Alzheimer’s disease. On May 9, it announced that PET scans of a patient with moderate Alzheimer’s showed a significant reduction in microglia activation associated with neuroinflammation after three months of treatment.

On July 21, the company announced an ‘unexpected discovery’ following immunologic analysis of the patient with Alzheimer’s disease: ‘The analysis revealed an increase in phagocytosis markers in classical monocytes, suggesting that nasal foralumab may enhance their ability to clear amyloid plaques. This unexpected effect may open new avenues for treating Alzheimer’s Disease by targeting both inflammation and amyloid accumulation.’

The company dosed the first patient in its randomized Phase 2 Alzheimer’s trial in December.

To end the year, Tiazana submitted a comprehensive safety report to the FDA documenting over 37 patient-years of treatment with no serious drug-related adverse events across its studies.

4. Spero Therapeutics (NASDAQ:SPRO)

Year-to-date gain: 119.05 percent
Market cap: US$129.58 million
Share price: US$2.30

Spero Therapeutics is developing novel treatments for rare diseases and multi-drug resistant bacterial infections with high unmet need.

The company’s lead drug candidate is tebipenem pivoxil hydrobromide (HBr), a late-stage development asset developed in collaboration with pharma giant GSK (NYSE:GSK). GSK has an exclusive license agreement to commercialize the drug candidate in most markets.

Tebipenem HBr is an oral carbapenem developed to treat complicated urinary tract infections (cUTIs), including pyelonephritis. The FDA granted tebipenem HBr qualified infectious disease product and fast-track designations.

Spero’s stock surged 245 percent on May 28 to reach US$2.35 after the company reported that its Phase 3 trial evaluating tebipenem HBr for treating cUTIs met its primary endpoint and stopped early for efficacy.

On December 19, GSK officially filed the new drug application resubmission to the FDA for tebipenem HBr for treating cUTIs supported by the Phase 3 results. This filing triggered a US$25 million milestone payment to Spero that is expected in Q1 2026.

5. OKYO Pharma (NASDAQ:OKYO)

Year-to-date gain: 60.50 percent
Market cap: US$74.85 million
Share price: US$1.91

OKYO Pharma is a clinical-stage biopharma company developing therapies for the treatment of neuropathic corneal pain and dry eye disease. Its lead candidate is urcosimod, a non-steroidal anti-inflammatory and non-opioid analgesic.

OKYO is currently evaluating urcosimod for the treatment of neuropathic corneal pain. The treatment received fast track designation from the FDA in May after the company ended its Phase 2 clinical trial early to analyze data.

On July 17, the company posted strong top-line data from the Phase 2 trial and stated it is planning a meeting with the FDA to discuss next steps for its lead drug candidate. The following day, OKYO received US$1.9 million in non-dilutive funding to support its clinical development of urcosimod.

In September, OKYO announced a 120 patient, multi-center multiple ascending dose clinical trial designed to identify the optimal dose for Phase 3 registration.

A scientific breakthrough followed on December 11, when new imaging data revealed that urcosimod may actually help restore corneal nerve structure, showing median increases in nerve fiber count and length, while those in the placebo group saw median decreases for both.

Securities Disclosure: I, Meagan Seatter, hold no direct investment interest in any company mentioned in this article.

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LaFleur Minerals Inc. (CSE: LFLR,OTC:LFLRF) (FSE: 3WK0) (‘LaFleur Minerals’ or the ‘Company’ or ‘Issuer’) is pleased to announce that, further to its news releases dated December 15, 2025, and December 16, 2025, the Company has completed its previously announced non-brokered private placement of units of the Company (the ‘LIFE Units’) at a price of $0.50 per Unit under the Listed Issuer Financing Exemption (as defined herein) for an upsized amount and gross proceeds of $4,695,000 (the ‘LIFE Offering’). The Company also announces that it has closed its previously announced Flow-Through Offering (the ‘FT Units’) at a price of $0.60 per flow-through unit for an oversubscribed amount and gross proceeds of $2,205,421.

With both these financings closed, upsized due to demand and oversubscribed, LaFleur is now funded for the restart of its Beacon Gold Mill, intending to source mineralized material from its nearby Swanson Gold Project, and starting with an estimated 10,000-20,000 metric tons (mt) of mineralized stockpiles remaining on the site of its wholly-owned Beacon Gold Mill.

FMI Securities Inc. acted as a special advisor and selling group member on the closed LIFE and FT Offerings, along with participation from other key investment banks and advisory firms such as Red Cloud Securities Inc., Ventum Financial Corp., Canaccord Genuity Group Inc., Research Capital Corp., Raymond James Ltd. and Stonegate Securities Ltd.

Beacon Gold Mill: A Strategic, High-Value Infrastructure Asset

The Company is uniquely positioned as one of the few junior gold companies in Canada that owns a fully permitted, existing gold mill, providing a clear pathway to cash flow without the long timelines, dilution, and capital intensity typically associated with mill construction. The completion of these financings materially de-risks LaFleur’s business model, enabling the Company to advance directly into gold production at its Beacon Gold Mill while simultaneously unlocking value from its nearby Swanson Gold Project. This vertically integrated strategy allows LaFleur to control the full value chain, from mineralized material to doré, creating the potential for early revenue generation, margin capture, and shareholder value accretion.

LaFleur’s wholly-owned Beacon Gold Mill represents a rare and highly strategic asset within the Abitibi Gold Belt. The 750 tpd mill is fully constructed, in good condition, permitted, historically proven, and ready for restart of operations, significantly reducing execution risk and capital requirements compared to greenfield development scenarios. With funding now secured, the Company intends to restart mill operations and advance toward gold production, with impending Preliminary Economic Assessment (‘PEA’) results expected mid-January, positioning LaFleur as the newest producer in one of the world’s most prolific gold districts. Led by Environmental Resources Management (ERM), a global mining, sustainability, and environmental consulting firm with extensive technical mining expertise, the PEA is conducted for the purpose of evaluating the restart of gold production at LaFleur’s wholly-owned and recently refurbished Beacon Gold Mill using mineralized material from its nearby Swanson Gold Deposit, both located in the recognized mining camp of Val-d’Or, Québec. Ownership of the Beacon Gold Mill provides LaFleur with operational flexibility and optionality, including the ability to process mineralized material from its own project and potentially third-party feed from regional deposits, creating additional revenue opportunities beyond its core assets.

Swanson Gold Project: High-Grade Feed Potential Close to the Mill

The Swanson Gold Project, located in close proximity to the Beacon Gold Mill, is a cornerstone of LaFleur’s production strategy. The project hosts various showings of high-grade gold mineralization within the Abitibi Greenstone Belt, positioned in an area renowned for producing over 200 million ounces of gold historically. The Company plans to advance Swanson as a primary source of mill feed, leveraging short haul distances to reduce operating costs and enhance project economics. With funding in place, LaFleur can aggressively advance exploration and development activities at Swanson, targeting the definition of near-surface, high-grade zones that could be rapidly transitioned into production. This approach supports a low-capex, staged production model designed to generate cash flow while continuing to grow the resource base.

Beacon-Swanson Synergy: A Clear Path to Value Creation

The combination of a wholly-owned, restart-ready gold mill and a nearby, district-scale gold project with high-grade potential, positions LaFleur Minerals as a differentiated junior gold company with a clear and executable growth strategy. Being funded enables the Company to move decisively toward production, reduce financing risk, and focus on operational execution. Management believes this milestone places LaFleur in a strong position to deliver near-term production, establish cash flow, and build a scalable gold platform in Québec, creating long-term value for shareholders as the Company advances toward becoming a sustainable gold producer.

Financing Details

Each Unit of the LIFE Offering consists of one common share in the capital of the Company (a ‘LIFE Share‘) and one transferrable common share purchase warrant (a ‘LIFE Warrant‘). Each Warrant entitled the holder to purchase one additional common share at a price of $0.75 for a period of 36 months from the date of issuance. Subject to compliance with applicable regulatory requirements and in accordance with National Instrument 45-106 – Prospectus Exemptions (‘NI 45-106‘), the LIFE Offering was made to purchasers’ resident in all provinces of Canada, except Quebec, pursuant to the listed issuer financing exemption under Part 5A of NI 45-106 (the ‘Listed Issuer Financing Exemption‘). The securities offered under the Listed Issuer Financing Exemption are not subject to a hold period in accordance with applicable Canadian securities laws.

Each Unit of the Flow-Through Offering consists of one common share in the capital of the Company, to be issued as a ‘flow-through share’ within the meaning of the Income Tax Act (Canada) and the Taxation Act (Québec) (each, a ‘FT Share‘), and one transferrable common share purchase warrant (a ‘FT Warrant‘). Each Warrant entitled the holder to purchase one additional common share at a price of $0.75 for a period of 24 months from the date of issuance. The Warrants are subject to an accelerated expiry upon thirty (30) business days’ notice from the Company in the event the closing price of the Company’s common shares on the Canadian Securities Exchange (the ‘CSE‘) is equal to or above a price of $0.90 for fourteen (14) consecutive trading days any time after closing of the Offering.

In connection with the LIFE and FT Offerings, the Company paid an aggregate cash finder fee of $480,229.43 and issued an aggregate of 909,466 non-transferable finders’ warrants (each, a ‘Finder’s Warrant‘). Each Finder’s Warrant entitles the holder to acquire one common share in the capital of the Company at a price of $0.75 each for a period of 24 months from the date of issuance, all in accordance with the policies of the CSE.

The gross proceeds from the LIFE Offering will be used for the advancement of exploration initiatives at the Company’s Swanson Gold Project and for operational purposes for the restart of gold production operations at the Company’s wholly-owned Beacon Gold Mill, in addition to working capital and general corporate expenses.

This news release is not an offer to sell or the solicitation of an offer to buy the securities in the United States or in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to qualification or registration under the securities laws of such jurisdiction. The securities referred to in this news release have not been, nor will they be, registered under the United States Securities Act of 1933, as amended (the ‘U.S. Securities Act’), and such securities may not be offered or sold within the United States or to, or for the account or benefit of, U.S. persons absent an exemption from registration under the U.S. Securities Act and applicable U.S. state securities laws. ‘United States’ and ‘U.S. person’ are as defined in Regulation S under the U.S Securities Act.

About LaFleur Minerals Inc.

LaFleur Minerals Inc. (CSE: LFLR,OTC:LFLRF) (FSE: 3WK0) is focused on the development of district-scale gold projects in the Abitibi Gold Belt near Val-d’Or, Québec. Our mission is to advance mining projects with a laser focus on our resource-stage Swanson Gold Deposit and the Beacon Gold Mill, which have significant potential to deliver long-term value. The Swanson Gold Project is approximately 18,304 hectares (183 km2) in size and includes several prospects rich in gold and critical metals previously held by Monarch Mining, Abcourt Mines, and Globex Mining. LaFleur has recently consolidated a large land package along a major structural break that hosts the Swanson, Bartec, and Jolin gold deposits and several other showings which make up the Swanson Gold Project. The Swanson Gold Project is easily accessible by road allowing direct access to several nearby gold mills, further enhancing its development potential. Lafleur Mineral’s fully refurbished and permitted Beacon Gold Mill is capable of processing over 750 tonnes per day and is being considered for processing mineralized material at Swanson and for custom milling operations for other nearby gold projects.

ON BEHALF OF LaFleur Minerals INC.

Paul Ténière, M.Sc., P.Geo.
Chief Executive Officer
E: info@lafleurminerals.com
LaFleur Minerals Inc.
1500-1055 West Georgia Street
Vancouver, BC V6E 4N7

Neither the Canadian Securities Exchange nor its Regulation Services Provider accepts responsibility for the adequacy or accuracy of this news release.

Cautionary Statement Regarding ‘Forward-Looking’ Information

This news release includes certain statements that may be deemed ‘forward-looking statements’. All statements in this new release, other than statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words ‘expects’, ‘plans’, ‘anticipates’, ‘believes’, ‘intends’, ‘estimates’, ‘projects’, ‘potential’ and similar expressions, or that events or conditions ‘will’, ‘would’, ‘may’, ‘could’ or ‘should’ occur. Forward-looking statements in this news release include, without limitation, statements related to the anticipated use of proceeds from the LIFE Offering. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in the forward-looking statements. Factors that could cause the actual results to differ materially from those in forward-looking statements include market prices, continued availability of capital and financing, and general economic, market or business conditions. Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of the Company’s management on the date the statements are made. Except as required by applicable securities laws, the Company undertakes no obligation to update these forward-looking statements in the event that management’s beliefs, estimates or opinions, or other factors, should change.

THIS NEWS RELEASE IS NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES FOR DISSEMINATION IN THE UNITED STATES

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Investor Insight

Silver Dollar Resources is repositioning its flagship La Joya silver-gold-copper project to unlock high-grade underground potential in Mexico’s prolific Durango-Zacatecas silver belt. Strengthened by the all-share sale of its Ranger-Page project to Bunker Hill Mining, the company offers investors leveraged exposure to near-term silver (zinc-lead) production in Idaho’s Silver Valley, while remaining fully funded to advance exploration across its core portfolio through 2026.

Overview

Silver Dollar Resources (CSE:SLV,OTCQX:SLVDF,FSE:4YW) is a precious metals exploration company focused on advancing high-grade silver and gold opportunities in Mexico. The company’s primary asset is the La Joya silver-gold-copper project, located in the southern portion of the Durango-Zacatecas silver belt, one of the world’s most productive silver regions.

La Joya has been the subject of extensive historical exploration, including more than 51,600 meters of drilling across 182 drill holes. This work outlined multiple mineralized zones, including the Main Mineralized Trend, Santo Niño and Coloradito. Silver Dollar is re-evaluating the project with an underground-focused exploration model, supported by structural analysis, underground sampling and reassessment of historic drill core to identify higher-grade targets at depth.

The company also owns the Nora silver-gold project in Durango, Mexico, which hosts the historic Candy mine and epithermal vein system that has returned high-grade surface sampling results. In addition, Silver Dollar holds an equity position in Bunker Hill Mining following the sale of the Ranger-Page project, providing equity exposure to the planned production restart in Idaho’s Silver Valley in the first 2026.

Silver Dollar is supported by an experienced management and technical team with expertise in underground exploration, epithermal systems and project evaluation. With a strong treasury, active exploration programs and multiple upcoming catalysts, the company is positioned to deliver exploration progress through 2026.

Company Highlights

  • 100 percent owned La Joya project, an advanced-stage silver-gold-copper system in Mexico’s Durango-Zacatecas silver belt
  • La Joya was originally proposed as an open pit in 2013 based on US$24 silver, US$1,200 gold and US$3 copper
  • Strategic shift toward evaluating La Joya’s high-grade underground potential supported by new 3D geological modeling, underground sampling, and drill target development
  • Completed sale of the Ranger-Page project to Bunker Hill Mining, providing equity exposure to a near-term US silver producer
  • Fully funded to carry out planned exploration programs through 2026
  • Largest shareholder is mining investor Eric Sprott, with approximately 17.5 percent ownership
  • Multiple exploration catalysts planned, including drilling at La Joya in early 2026

Key Projects

La Joya Silver-Gold-Copper Project

Rock sample and geologist examining a rock formation in Silver Dollar Resources

The La Joya project is Silver Dollar’s 100 percent owned flagship asset. It is located within the Durango-Zacatecas silver belt, which hosts numerous past-producing and operating mines, including assets operated by First Majestic Silver, Grupo México, Industrias Peñoles and Pan American Silver.

Historical exploration at La Joya outlined multiple zones of mineralization, including the Main Mineralized Trend, Santo Niño and Coloradito, with mineralization occurring as skarn, replacement and vein-style systems. Previous work was largely oriented toward evaluating open-pit potential.

Silver Dollar is advancing a reinterpretation of La Joya as a potential high-grade underground system. Recent work includes:

  • Underground sampling from historic workings, returning values of up to 2,753 grams per metric ton (g/t) silver equivalent
  • Identification of the Central Dyke zone over approximately 770 meters, including a sample returning 3,513 g/t (~124 oz/ton) silver
  • Discovery of the Brazo zone, located approximately 1 kilometer west of the Main Mineralized Trend, with Phase II drilling returning up to 451 g/t silver over 5 meters
  • The Brazo Zone provides evidence of deeper, high-grade mineralization at La Joya
  • Development of new 3D geological models is in progress incorporating the large database of structural, geochemical and fault-kinematic analysis

Silver Dollar plans to advance a new phase of drilling at La Joya in the first quarter of 2026, with a focus on testing high-grade underground targets identified through recent modeling and sampling.

Nora Silver-Gold Project

The Nora project is located in Durango, Mexico, within the same regional silver trend as several major operations. The property hosts an epithermal vein system known as the Candy vein.

Geological mapping and surface sampling have returned high-grade gold, silver and base metal values, including samples grading up to 29.61 g/t gold and 2,215 g/t silver, along with locally elevated copper, lead and zinc values.

In 2025, Silver Dollar identified the North Canyon zone, located approximately 1.5 kilometers north of the historic Candy mine. Channel sampling returned 162 g/t silver equivalent over 12.48 meters within a broad oxidation zone. Ongoing mapping and trenching are being used to define drill targets for potential drill testing in the first quarter of 2026.

Ranger-Page Project (Sold)

Silver Dollar acquired the Ranger-Page silver-lead-zinc project in Idaho’s Silver Valley in August 2024 and agreed to sell the asset to neighbor Bunker Hill Mining in October 2025 for C$3.5 million, payable by the issuance of 23,333,334 Bunker Hill shares at a deemed price of C$0.15 per share. The sale closed in December and the value of those Bunker Hill shares at the time of closing was approximately $5.8 million.

The Ranger-Page project is geologically contiguous with the Bunker Hill mine system. The transaction provides Silver Dollar with equity exposure to Bunker Hill’s planned production restart in the first half of 2026. Teck Resources owns ~32 percent of Bunker Hill and has life-of-mine off-take agreement for 100 percent of the zinc and lead production. Silver Dollar expects Bunker Hill to receive increased analyst coverage and a higher valuation next year as production commences.

Red Lake Area Properties

Silver Dollar also holds two 100 percent owned gold grassroots exploration properties in Ontario’s Red Lake mining division: Pakwash Lake and Longlegged Lake. Early-stage work has included airborne magnetic surveys, geological mapping and surface sampling, identifying structural and geophysical targets associated with the Pakwash Lake Fault Zone.

While not a primary focus, the properties provide optionality in a well-established gold district with major Kinross Gold discovery drilling on the Dixie Halo property that adjoins both properties to the north.

Management Team

Gregory Lytle — President, CEO and Director

Gregory Lytle has more than 20 years of experience advising mineral exploration companies on corporate strategy, capital markets and communications. Prior to becoming CEO in 2025, Lytle served as a consultant to Silver Dollar and has facilitated more than $100 million in financings for mining-sector clients.

J.J. (Jeff) Smulders — CFO, Corporate Secretary and Director

Jeff Smulders has more than 45 years of experience in accounting, taxation and financial management. He has provided financial consulting services to public and private companies for more than 25 years.

Bruce MacLachlan — Independent Director

Bruce MacLachlan is an exploration professional with more than four decades of experience across grassroots and advanced-stage projects. He has worked with companies including Noranda, Hemlo Gold, Battle Mountain and Noront.

Guillermo Lozano-Chávez — Independent Director

Guillermo Lozano-Chávez is a geologist with more than 40 years of experience in exploration and mine management across the Americas. He previously served as vice president of exploration at First Majestic Silver.

Dale Moore — Exploration Manager and Qualified Person

Dale Moore is an underground-focused geologist with more than a decade of experience in Idaho’s Coeur d’Alene Mining District. His work includes major deposits such as Lucky Friday and the Galena Complex, and he leads technical work at La Joya.

Mark Malfair — Country Manager, Mexico

Mark Malfair is a bilingual geologist with more than 25 years of experience in exploration and project management in Mexico, including previous work at Chesapeake Gold’s Metates project.

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NOT FOR DISTRIBUTION TO UNITED STATES NEWS WIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES

Stallion Uranium Corp. (the ‘Company’ or ‘Stallion’) (TSX-V: STUD; OTCQB: STLNF; FSE: B76) is pleased to announce that, further to its news releases dated December 12, 2025 and December 17, 2025, it has increased its non-brokered private placement to raise gross proceeds of $7,723,064 (the ‘Offering’). The Company also announces that it has closed the Offering, issuing 17,162,365 flow-through shares of the Company as a ‘flow-through share’ within the meaning of the Income Tax Act (Canada) (each, a ‘FT Share’) at a price of $0.45 per FT Share.

The gross proceeds from the FT Shares will be used by the Company to incur eligible ‘Canadian exploration expenses’ that qualify as ‘flow-through critical mineral mining expenditures’ as such terms are defined in the Income Tax Act (Canada) (the ‘Qualifying Expenditures‘) related to the Company’s uranium projects in the Athabasca Basin, Saskatchewan, on or before December 31, 2026. All Qualifying Expenditures will be renounced in favour of the subscribers of the FT Shares effective December 31, 2025.

The FT Shares issued pursuant to the Offering are subject to a four-month and one day hold period from the date of issuance under applicable Canadian securities laws.

In connection with the closing of the Offering, the Company paid the following cash fees to eligible arm’s length finders: $24,728 to Canaccord Genuity Corp., $353,524.84 to Accilent Capital Management Inc., $3,465 to Research Capital Corporation, $70,000 to PB Markets Inc., $47,250 to GloRes Securities Inc.; $28,000 to Wealth (WCPD Inc.), and $3,150 to Sightline Wealth Management.

This press release does not constitute an offer to sell or a solicitation of an offer to buy any of the securities in the United States. The securities have not been and will not be registered under the United States Securities Act of 1933, as amended (the ‘U.S. Securities Act‘), or any state securities laws and may not be offered or sold within the United States or to or for the account or benefit of a U.S. person (as defined in Regulation S under the U.S. Securities Act) unless registered under the U.S. Securities Act and applicable state securities laws or an exemption from such registration is available.

About Stallion Uranium Corp.:

Stallion Uranium is working to ‘Fuel the Future with Uranium’ through the exploration of roughly 1,700 sq/km in the Athabasca Basin, home to the largest high-grade uranium deposits in the world. The company, with JV partner Atha Energy holds the largest contiguous project in the Western Athabasca Basin adjacent to multiple high-grade discovery zones. With a commitment to responsible exploration and cutting-edge technology such as the use of the proprietary Haystack TI technology, Stallion is positioned to play a key role in the future of clean energy.

Our leadership and advisory teams are comprised of uranium and precious metals exploration experts with the capital markets experience and the technical talent for acquiring and exploring early-stage properties. For more information visit stallionuranium.com.

On Behalf of the Board of Stallion Uranium Corp.:

Matthew Schwab
CEO and Director

Corporate Office:
700 – 838 West Hastings Street,
Vancouver, British Columbia,
V6C 0A6

T: 604-551-2360
info@stallionuranium.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release contains forward-looking statements and forward-looking information within the meaning of Canadian securities legislation (collectively, ‘forward-looking statements’) that relate to the Company’s current expectations and views of future events. Any statements that express, or involve discussions as to, expectations, beliefs, plans, objectives, assumptions or future events or performance (often, but not always, through the use of words or phrases such as ‘will likely result’, ‘are expected to’, ‘expects’, ‘will continue’, ‘is anticipated’, ‘anticipates’, ‘believes’, ‘estimated’, ‘intends’, ‘plans’, ‘forecast’, ‘projection’, ‘strategy’, ‘objective’ and ‘outlook’) are not historical facts and may be forward-looking statements and may involve estimates, assumptions and uncertainties which could cause actual results or outcomes to differ materially from those expressed in such forward-looking statements. No assurance can be given that these expectations will prove to be correct and such forward-looking statements included in this material change report should not be unduly relied upon. These statements speak only as of the date they are made.

Forward-looking statements are based on a number of assumptions and are subject to a number of risks and uncertainties, many of which are beyond the Company’s control, which could cause actual results and events to differ materially from those that are disclosed in or implied by such forward-looking statements. The Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law. New factors emerge from time to time, and it is not possible for the Company to predict all of them or assess the impact of each such factor or the extent to which any factor, or combination of factors, may cause results to differ materially from those contained in any forward-looking statement. Any forward-looking statements contained in this presentation are expressly qualified in their entirety by this cautionary statement.

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Biotech is a dynamic industry that is driving scientific advances and innovation in healthcare. In Canada, the biotech sector is home to companies pursuing cutting-edge therapies and medical technologies.

Read on to learn what’s been driving these Canadian biotech firms.

1. Eupraxia Pharmaceuticals (TSX:EPRX)

Year-on-year gain: 136.75 percent
Market cap: C$507.5 million
Share price: C$10.63

Eupraxia Pharmaceuticals is developing clinical candidates that employ its DiffuSphere technology, which delivers treatments to the targeted tissues.

The company’s candidates are currently EP-104GI for eosinophilic esophagitis and EP-104IAR for knee osteoarthritis, and it is exploring the use of its technology for other active compounds as well.

The company has continued to advance the treatment through clinical trials in 2025 and released multiple rounds of positive data from its Phase 1b/2a trial cohorts.

In July, Eupraxia dosed its first patient after advancing its investigation to Phase 2b trials based on safety and efficacy data from the earlier Phase 2a patient cohorts. Top-line results from the Phase 2b study are anticipated in Q3 2026.

In September, the company shared data from the highest-dose cohort of the still ongoing Phase 1b/2a trials, reporting that the group saw the largest improvements so far. Backed by a US$80.5 million public offering completed in September, Eupraxia ends 2025 capitalized through Q1 2028, the company stated.

2. NervGen (TSXV:NGEN)

Year-on-year gain: 123.08 percent
Market cap: C$562.67 million
Share price: C$6.96

NervGen is a clinical-stage Canadian biotechnology company that focuses on developing innovative treatments to enable the nervous system to repair itself following damage from injury or disease.

The company’s core technology targets a mechanism that hinders nervous system repair. When the nervous system is damaged, chondroitin sulfate proteoglycans (CSPG) form a “scar.” Initially, CSPGs help contain damage, but their long-term interaction with the PTPσ receptor inhibits repair.

NervGen’s lead drug candidate, NVG-291, is designed to relieve these inhibitory effects to promote nervous system repair. It received fast-track designation from the US FDA.

On November 24, 2025, the company announced expanded data from its Phase 1b/2a clinical trial testing NVG-291 in patients with chronic spinal cord injury. The results showed ‘unprecedented durable’ improvements in patients, with functional gains continuing to strengthen after the 12 week treatment period ended.

Compared to placebo, more patients who received the treatment reported substantially improved bladder control and muscle spasticity, and GRASSP quantitative prehension scores demonstrating a 3.7-fold greater mean improvement in hand function.

NVG-300, a newer preclinical candidate, is being evaluated for ischemic stroke and SCI.

3. Bright Minds Biosciences (CSE:DRUG)

Year-on-year gain: 103.83 percent
Market cap: C$918.89 million
Share price: C$110.72

Bright Minds Biosciences is developing novel serotonin agonists targeting neurocircuit abnormalities linked to neuropsychiatric disorders and epilepsy, designing next-generation treatments that aim to retain the therapeutic benefits of psychedelics while minimizing side effects.

Its lead candidate, BMB-101, a selective 5-HT2C receptor agonist, has shown encouraging preclinical efficacy by stopping seizures in an epilepsy mouse model, evaluated jointly with Firefly Neuroscience (NASDAQ:AIFF).

The company’s stock surged nearly 1,500 percent in October 2024 following H. Lundbeck’s acquisition announcement of a competitor focused on similar targets. Strengthening its epilepsy expertise, Bright Minds expanded its scientific advisory board in early 2025 by adding five leaders in the field.

In 2025, Bright Minds launched the BREAKTHROUGH study, an open-label Phase 2 trial evaluating BMB-101 in adults with absence epilepsy or developmental and epileptic encephalopathy.

Clinical updates presented at the American Epilepsy Society Annual Meeting on December 7 highlighted BMB-101’s unique G-protein biased agonism, which aims to provide anti-seizure efficacy without the cardiovascular risks typical of older serotonin drugs. The same month, Bright Minds company expanded its scope by initiating a new Phase 2a program investigating BMB-101 for Prader-Willi Syndrome.

4. Hemostemix (TSXV:HEM)

Year-on-year gain: 21.43 percent
Market cap: C$16.02 million
Share price: C$0.09

Hemostemix is a clinical-stage biotech company focused on developing autologous stem cell therapies, meaning the treatments use a patient’s own cells to theoretically enhance safety and efficacy.

Its main product, ACP-01, is an autologous cell therapy designed to promote tissue repair and regeneration in areas affected by diseases, including a range of heart diseases.

The company announced its first advanced sales orders for ACP-01 in Q1 2025 and has been working to expand internationally and attract new investment.

Hemostemix secured the regulatory green light for commercial sales in Florida after the state passed Senate Bill 1768. The bill creates a framework in which healthcare providers can administer stem cell therapies that had not yet been approved by the US Food and Drug Administration (FDA) but meet the bill’s guidelines.

The company now offers commercial ACP-01 treatments for ischemic pain in the state under the name VesCell, with sales forecasted to reach C$22.5 million in 2026. Operational plans target cash flow positivity by Q4 2026, supported by a growing physician network and commercial pipeline.

Additionally, Hemostemix is currently collaborating with Firefly Neuroscience on a Phase 1 clinical trial of ACP-01 for vascular dementia.

A pre-IND meeting, aiming to finalize a single Phase 1 clinical trial designed to study ACP-01 across multiple conditions simultaneously, is scheduled for January 16, 2026.

Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.

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VANCOUVER, BC / ACCESS Newswire / December 30, 2025 / Electric Royalties Ltd. (TSXV:ELEC,OTC:ELECF)(OTCQB:ELECF) (‘Electric Royalties’ or the ‘Company’) announces that Gleason & Sons LLC (the ‘Lender’) has elected to convert C$420,000.00 of accrued interest on the principal amount of the Company’s convertible credit facility (the ‘Interest’) under the amended and restated convertible loan agreement dated February 16, 2024 between the Lender and Company (the ‘A&R Agreement’), into 3,000,000 common shares of the Company (the ‘Conversion Shares’), at a conversion price of C$0.14 per Conversion Share (the ‘Interest Conversion’). Subject to acceptance of the TSX Venture Exchange (the ‘TSXV’), the Company expects to issue the Conversion Shares in December 2025.

‘Today’s conversion virtually zeroes out all interest accrued to date. We appreciate the ongoing support of our largest shareholder Stefan Gleason as the Company’s diversified portfolio of 43 royalties continues to develop and mature,’ said Electric Royalties CEO Brendan Yurik. ‘As we head into 2026, we are pleased with our growing cash flows from the Punitaqui copper mine in Chile, the announced investment commitment by the U.S. government, Nrystar, and Korea Zinc related to our past-producing Middle Tennessee Zinc royalty, and the numerous other portfolio developments we shared with the market in recent weeks.’

The Interest Conversion is treated as a ‘Shares for Debt’ transaction under Policy 4.3 of the TSX Venture Exchange (the ‘TSXV’), and the Interest shall be settled in consideration for the Conversion Shares, upon the terms of the A&R Agreement. Completion of the Interest Conversion is subject to the approval of the TSX Venture Exchange. All of the Conversion Shares issuable in connection with the Interest Conversion will bear applicable resale legends restricting the transfer of said Conversion Shares, including for a period of four months and one day from the distribution date under Canadian securities laws, and for a period of six months under U.S. securities laws.

The ‘related party transaction’ requirements under Policy 5.9 of the TSXV and Multilateral Instrument 61-101 – Protection of Minority Security Holders in Special Transactions (‘MI 61-101’) do not apply as the Interest Conversion meets the exemption set forth under Section 5.1(h)(iii) of MI 61-101.

Stock Options

The Company announces that it has granted incentive stock options (the ‘Options’) to certain consultants, under the terms of the Company’s stock option plan, to purchase an aggregate of 700,000 common shares in the capital stock of the Company. The Options were granted at an exercise price of $0.14 per share for a three-year term. The stock option grant is subject to acceptance by the TSX Venture Exchange.

About Electric Royalties Ltd.

Electric Royalties is a royalty company established to take advantage of the demand for a wide range of commodities (lithium, vanadium, manganese, tin, graphite, cobalt, nickel, zinc and copper) that will benefit from the drive toward electrification of a variety of consumer products: cars, rechargeable batteries, large scale energy storage, renewable energy generation and other applications.

Electric vehicle sales, battery production capacity and renewable energy generation are slated to increase significantly over the next several years and with it, the demand for these targeted commodities. This creates a unique opportunity to invest in and acquire royalties over the mines and projects that will supply the materials needed to fuel the electric revolution.

Electric Royalties has a growing portfolio of 43 royalties in lithium, vanadium, manganese, tin, graphite, cobalt, nickel, zinc and copper across the world. The Company is focused predominantly on acquiring royalties on advanced stage and operating projects to build a diversified portfolio located in jurisdictions with low geopolitical risk, which offers investors exposure to the clean energy transition via the underlying commodities required to rebuild the global infrastructure over the next several decades toward a decarbonized global economy.

Company Contact

Brendan Yurik
CEO, Electric Royalties Ltd.
Phone: (604) 364‐3540
Email: Brendan.yurik@electricroyalties.com
https://www.electricroyalties.com/

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange), nor any other regulatory body or securities exchange platform, accepts responsibility for the adequacy or accuracy of this release.

Cautionary Statements Regarding Forward-Looking Information and Other Company Information

This news release includes forward-looking information and forward-looking statements (collectively, ‘forward-looking information’) with respect to the Company within the meaning of Canadian securities laws. This news release includes information regarding other companies and projects owned by such other companies in which the Company holds a royalty interest, based on previously disclosed public information disclosed by those companies and the Company is not responsible for the accuracy of that information, and that all information provided herein is subject to this Cautionary Statement Regarding Forward-Looking Information and Other Company Information. Forward looking information is typically identified by words such as: believe, expect, anticipate, intend, estimate, postulate and similar expressions, or are those, which, by their nature, refer to future events. This information represents predictions and actual events or results may differ materially. Forward-looking information may relate to the Company’s future outlook and anticipated events and may include statements regarding the financial results, future financial position, expected growth of cash flows, business strategy, budgets, projected costs, projected capital expenditures, taxes, plans, objectives, industry trends and growth opportunities of the Company and the projects in which it holds royalty interests.

While management considers these assumptions to be reasonable, based on information available, they may prove to be incorrect. Forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of the Company or these projects to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks, uncertainties and other factors include, but are not limited to risks associated with general economic conditions; adverse industry events; marketing costs; loss of markets; future legislative and regulatory developments involving the renewable energy industry; inability to access sufficient capital from internal and external sources, and/or inability to access sufficient capital on favourable terms; the mining industry generally, recent market volatility, income tax and regulatory matters; the ability of the Company or the owners of these projects to implement their business strategies including expansion plans; competition; currency and interest rate fluctuations, and the other risks.

The reader is referred to the Company’s most recent filings on SEDAR+ as well as other information filed with the OTC Markets for a more complete discussion of all applicable risk factors and their potential effects, copies of which may be accessed through the Company’s profile page at sedarplus.ca and at otcmarkets.com.

SOURCE: Electric Royalties Ltd

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