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Canadian company PMET Resources (ASX:PMT, TSX:PMET, OTCQX:PMETF) has completed a lithium-only feasibility study on the CV5 deposit of its Shaakichiuwaanaan lithium project in Northern Quebec.

The company said that the feasibility study confirms that the project is a large-scale and lifelong operation, with CV5’s maiden reserve updated to 84.3 million tonnes (Mt) at 1.26 percent lithium oxide or about 2.62 Mt lithium carbonate equivalent (LCE) in probable reserves.

Results also show that there is still potential to upgrade and expand resources at CV5 and its nearby CV13 deposit, which currently hold a total resource of 108.0 million tonnes at 1.40 percent indicated and 33.4 at 1.33 percent inferred.

“Our large scale and long-life project is ideally suited to support the emerging American, European, and Asian lithium raw materials supply chains,” commented CEO and President Ken Brinsden.

“There are very few projects of this size & scale, quality, and low production cost that can assist in underwriting the expected capital investment supporting new supply chains and demand growth in western markets.”

Located in Quebec’s Eeyou Istchee James Bay region, Shaakichiuwaanaan is recognised as the largest lithium pegmatite mineral resource in the Americas.

It is also among the largest lithium mines in the world, with potential to become the second largest following the Greenbushes lithium operations in Western Australia.

Greenbushes is owned by Albemarle (NYSE:ALB) and was recorded with an estimated 0.21 metric tonnes per annum lithium production in 2023.

PMET is targeting a final investment decision for Shaakichiuwaanaan for the second half of 2027, hoping that “the overall market supply-demand balance tightens over the coming years.”

Researchers found that the project can have an annual production of up to 800,000 tonnes of lithium-rich rock, along with pollucite, tantalite, and cesium.

Brinsden said that about 20 percent of the jobs created at Shaakichiuwaanaan will be allotted to workers at the Cree territory.

PMET Resources was formerly Patriot Battery Metals. The company officially changed its name in September.

Securities Disclosure: I, Gabrielle de la Cruz, hold no direct investment interest in any company mentioned in this article.

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Here’s a quick recap of the crypto landscape for Friday (October 24) as of 5:00 p.m. UTC.

Get the latest insights on Bitcoin, Ether and altcoins, along with a round-up of key cryptocurrency market news.

Bitcoin and Ether price update

Bitcoin (BTC) was priced at US$110,271, a 0.8 percent decrease in 24 hours. Its lowest valuation of the day was US$109,478, and its highest was US$111,658.

Bitcoin price performance, October 24, 2025

Bitcoin price performance, October 24, 2025

Chart via TradingView

Bitcoin’s medium-sized investors are continuing to buy even after the US$19 billion liquidation event earlier this month, preserving the market’s long-term bullish structure, according to CryptoQuant.

Entities holding between 100 and 1,000 BTC have added roughly 907,000 BTC over the past year, which analysts say represents a strong accumulation trend that historically aligns with upward price momentum.

However, CryptoQuant warned that short-term demand is softening as the cohort’s 30-day balance has fallen below its moving average, suggesting potential near-term caution until a catalyst, such as renewed ETF inflows, emerges.

Meanwhile, Ether (ETH) was priced at US$3,888.22, a 0.7 percent decrease in 24 hours. Its lowest valuation of the day was US$3,824.85, and its highest was US$3,994.25.

Altcoin price update

  • Solana (SOL) was priced at US$190.41, down by 0.8 percent over the last 24 hours. Its lowest valuation of the day was US$188.87, and its highest was US$194.57.
  • XRP was trading for US$2.48, an increase of 2.5 percent over the last 24 hours. Its lowest valuation of the day was US$2.38, while its highest was US$2.51.

Crypto derivatives and market indicators

Bitcoin derivatives metrics indicate a complex market environment with mixed signals.

Bitcoin liquidations have totaled approximately US$12.4 million in the last four hours, with long positions making up the majority, indicating selling pressure from a long squeeze and short-term bearish momentum. Ether liquidations show a similar pattern, totaling US$18.49 million during the period, the majority of which were also long positions.

Futures open interest for Bitcoin has increased by about 1.7 percent to roughly US$71.35 billion, showing modestly higher positioning after the recent flush. Ether futures open interest was essentially unchanged at around US$45.80 billion.

Fear and Greed Index snapshot

CMC Crypto Fear and Greed Index, Bitcoin price and Bitcoin volume.

CMC Crypto Fear and Greed Index, Bitcoin price and Bitcoin volume.

Chart via CoinMarketCap

CMC’s Crypto Fear & Greed Index has slightly trended upwards into 32 but remains in fear territory, an improvement from this week’s lowest score (25).

Today’s crypto news to know

Trump pardons Binance founder

US President Donald Trump has granted a full pardon to Binance founder Changpeng Zhao, wiping away his 2024 conviction for violating US anti–money laundering laws.

Zhao, better known as “CZ,” served four months in prison and had been barred from running financial ventures under the plea deal.

The move follows months of lobbying by Binance, which paid a record US$4.3 billion fine as part of its own settlement with federal prosecutors. White House Press Secretary Karoline Leavitt called the case “a politically motivated overreach by the Biden administration,” insisting the pardon was meant to correct an injustice.

Critics argue the decision reflects Trump’s growing financial ties to the crypto industry, citing his personal investments and recent push for a “national cryptocurrency reserve.”

Zhao thanked Trump on social media, saying he was “deeply grateful” for the decision and eager to “continue supporting innovation responsibly.”

JPMorgan to let institutions borrow against Bitcoin, Ethereum holdings

JPMorgan Chase & Co. (NYSE:JPM) is preparing to let institutional clients borrow cash using Bitcoin and Ethereum as collateral.

Set to launch by the end of 2025, the initiative will allow clients to pledge crypto directly rather than through ETFs, using a third-party custodian to safeguard tokens. The pilot follows successful internal testing involving BlackRock’s iShares Bitcoin Trust earlier this year.

JPMorgan already accepts crypto-linked ETFs as loan collateral and integrates blockchain tools into its commercial lending network.

Polymarket confirms POLY Token launch after US$2B investment surge

Prediction platform Polymarket has confirmed plans to launch its long-awaited POLY token following a massive US$2 billion investment from Intercontinental Exchange (ICE), the parent company of the New York Stock Exchange.

Speaking on the Degenz Live podcast, Chief Marketing Officer Matthew Modabber said both the token and airdrop are “officially in motion,” confirming rumors that have swirled for months.

Modabber emphasized that the launch will prioritize real utility and “long-term viability,” aligning with Polymarket’s push to relaunch its US app after receiving fresh regulatory clearance.

Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.

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(TheNewswire)

Angkor Resources Corp.

GRANDE PRAIRIE, ALBERTA TheNewswire – October 24, 2025 – Angkor Resources Corp. (TSXV: ANK,OTC:ANKOF) (‘ANGKOR’ OR ‘THE COMPANY’) announces it has finalized the sale of all mineral rights on Oyadao North license to Almighty Natural Resources (‘Almighty’).

Angkor negotiated a sale of mineral rights of the Oyadao North license to Almighty Natural Resources and announced on June 26, 2024.   After delays from Almighty, the Company received $325,000 US as the final cash component in the transfer of license to Almighty and signed a 4% Net Smelter Royalty for Angkor to receive on production revenue from any mineral recovered and produced from the Oyadao North license.  The Company provided written confirmation to the Ministry of Mines and Energy of its agreement to transfer mineral rights.

Hommy Resources Ltd., holding a 30% interest in the property, chose to receive shares for their entire interest in the sale of the license, and participated in the shares for debt announced on Sept 23, 2025 receiving a total of 542,857 common shares of Angkor.

With final documentation completed on the disposition, Angkor continues with its priority projects of Block VIII onshore oil and gas, and its two remaining mineral licenses, Andong Meas in Ratanakiri and Andong Bor, which straddles Oddar Meanchey and Banteay Meanchey provinces in northwest Cambodia.

==================================================================

ABOUT Angkor Resources CORPORATION:

Angkor Resources Corp. is a public company, listed on the TSX-Venture Exchange, and is a leading resource optimizer in Cambodia working towards mineral and energy solutions across Canada and Cambodia.   Since 2022, Angkor’s Canadian subsidiary, EnerCam Exploration Ltd., has been involved in gas/carbon capture and oil and gas production in Saskatchewan, Canada.  ANGKOR’s carbon capture and gas conservation project is part of its long-term commitment to Environmental and Social projects and cleaner energy solutions across jurisdictions.

The company’s mineral subsidiary, Angkor Gold Corp. in Cambodia holds two mineral exploration licenses in Cambodia with multiple prospects in copper and gold.

Its Cambodian energy subsidiary, EnerCam Resources, was granted an onshore oil and gas license of 7300 square kilometers in the southwest quadrant of Cambodia called Block VIII.   The company then removed all parks and protected areas and added 220 square kilometers, making the just over 4095 square kilometers.  EnerCam is actively advancing oil and gas exploration onshore Cambodia to meet its mission of discovering and proving commercial oil and gas in Cambodia.

CONTACT: Delayne Weeks – CEO

Email: info@angkorresources.com Website: angkor resources.com Telephone: +1 (780) 831-8722

Please follow @AngkorResources on , , , Instagram and .

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Certain information set forth in this news release may contain forward-looking statements that involve substantial known and unknown risks and uncertainties. These forward-looking statements are subject to numerous risks and uncertainties, certain of which are beyond the control of the Company, including, but not limited to the potential for gold and/or other minerals at any of the Company’s properties, the prospective nature of any claims comprising the Company’s property interests, the impact of general economic conditions, industry conditions, dependence upon regulatory approvals, uncertainty of sample results, timing and results o f future exploration, and the availability of financing.  Readers are cautioned that the assumptions used in the preparation of such information, although considered reasonable at the time of preparation, may prove to be imprecise and, as such, undue reliance should not be placed on forward-looking statements.

Copyright (c) 2025 TheNewswire – All rights reserved.

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Duane Nelson, President and Chief Executive Officer, Torchlight Innovations Inc. (TSXV: RZL) (‘Company’), and its executive management team, joined Omar Khafagy, Head Client Success, Toronto Stock Exchange (‘TSX’), to open the market and celebrate the Company’s new listing on TSX Venture Exchange.

Torchlight Innovations Inc., doing business as RZOLV Technologies (‘RZOLV’), is a Canadian clean-technology company redefining the $240 billion global gold mining sector. Their proprietary RZOLV™ formula provides a safer, more eco-friendly alternative to the $2B of cyanide used annually. RZOLV delivers similar leach kinetics and recoveries—at similar costs on ores, concentrates, and tailings. The Company is transitioning from pilot to commercial rollout with strong industry partnerships and recurring-revenue potential from reagent sales and licensing agreements. As the mining sector accelerates toward ESG-aligned operations, RZOLV stands at the intersection of profit and sustainability—offering investors scalable exposure to one of the most transformative shifts in modern resource extraction.

MEDIA CONTACT:
Duane Nelson
President & CEO
604-512-8118

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/271794

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Thor Energy (ASX:THR,LSE:THR,OTCQB:THORF) has finalized a binding agreement with US-based DISA Technologies to treat abandoned uranium mine waste in Colorado to recover saleable uranium and other critical minerals as well.

Under the agreement, DISA will deploy its patented High-Pressure Slurry Ablation (HPSA) technology at Thor’s Colorado uranium projects, which are held through its US subsidiary, Standard Minerals. The company owns 25 percent of the uranium mineral rights, while the remaining 75 percent is held by London-listed Metals One (LSE:MET1).

Thor said it will receive a share of gross revenues generated from the sale of uranium and critical mineral concentrates recovered from the sites, with no capital or operating expenditures required on its part.

“This agreement finalises the details under which Thor will potentially generate revenue from the recovery of uranium and critical metals from its Colorado projects,” said Andrew Hume, Thor’s managing director and CEO.

“It is also fantastic to report that the US Nuclear Regulatory Commission has granted DISA a Service Provider’s License to remediate abandoned uranium mine waste. DISA is now the first company in the US to receive such approvals.”

DISA’s newly granted Service Providers License (SPL) from the US Nuclear Regulatory Commission (NRC) allows it to proceed with remediation of legacy uranium waste sites across the country.

The license, secured after a multi-year review process that began in 2021, enables DISA to operate modular mobile treatment plants using HPSA technology, a process designed to recover valuable resources from waste while mitigating environmental hazards.

Under the agreement, DISA will act as the project operator, responsible for all costs related to evaluation, permitting, treatment, and remediation.

Meanwhile, Thor, through Standard Minerals, will receive between 2.5 and 4 percent of gross product sales, depending on market conditions.

Beyond resource recovery, the process is expected to deliver environmental benefits by improving water quality and restoring legacy mine sites to productive use.

The project aligns closely with recent US policy efforts to unlock domestic mineral supplies from legacy sites. The Department of the Interior’s Secretarial Order No. 3436, issued earlier this year, directs agencies to accelerate recovery of critical and strategic minerals from mine waste and streamline permitting processes.

Next steps for Thor and DISA include conducting a detailed characterization program using assays and gamma probes to determine the quantity of recoverable minerals in the waste dumps.

Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

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/NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR FOR RELEASE, PUBLICATION, DISTRIBUTION OR DISSEMINATION DIRECTLY, OR INDIRECTLY, IN WHOLE OR IN PART, IN OR INTO THE UNITED STATES./

Quimbaya Gold Inc. (‘Quimbaya’ or the ‘Company’) (CSE:QIM,OTC:QIMGF) (OTCQB: QIMGF) (FSE: K05) is pleased to announce that due to investor demand, it has entered into an amended agreement with Stifel Canada to act as sole underwriter and bookrunner (the ‘Underwriter’), to increase the size of its previously announced ‘bought deal’ private placement offering, pursuant to which the Underwriter has agreed to purchase on a bought deal basis, 17,900,000 units of the Company  (the ‘LIFE Units’) at a price of C$0.70 per LIFE Unit (the ‘Offering Price’) for aggregate gross proceeds of C$12,530,000 (the ‘Offering’), with the LIFE Units to be issued pursuant to the Listed Issuer Financing Exemption (as defined below). 

The Company has granted to the Underwriter an option, exercisable up to 48 hours prior to the closing date, to purchase for resale up to an additional 15% of LIFE Units at the Offering Price for additional gross proceeds of up to C$1,879,500

Each LIFE Unit will consist of one common share (a ‘Common Share‘) and one-half (½) of one Common Share purchase warrant (each whole warrant, a ‘Warrant‘) of the Company. Each Warrant will be exercisable to acquire one Common Share for a period of 36 months following the closing date of the Offering at an exercise price of C$1.00 per common share.

The net proceeds from the Offering are expected to be used to advance the Company’s exploration programs, including drilling at the Tahami South project and follow-up work on regional copper-gold and gold targets, as well as for general working capital.

Subject to compliance with applicable regulatory requirements and in accordance with National Instrument 45-106 – Prospectus Exemptions (‘NI 45-106‘), the LIFE Units will be offered for sale to purchasers resident in Canada other than Quebec and/or other qualifying jurisdictions pursuant to the listed issuer financing exemption under Part 5A of NI 45-106 (the ‘Listed Issuer Financing Exemption‘). Because the Offering is being completed pursuant to the Listed Issuer Financing Exemption, the LIFE Units issued pursuant to the Offering will not be subject to a hold period pursuant to applicable Canadian securities laws. There is an offering document related to the Offering that can be accessed under the Company’s issuer profile on SEDAR+ at www.sedarplus.ca and on the Company’s website at quimbayagold.com. Prospective investors should read the offering document before making an investment decision.

The Offering is scheduled to close on or about November 4, 2025 (the ‘Closing Date‘) and is subject to certain conditions including, but not limited to, the receipt of all necessary regulatory and other approvals including the acceptance of the Canadian Securities Exchange.

The securities referred to in this news release have not been and will not be registered under the United States Securities Act of 1933, as amended (the ‘U.S. Securities Act‘), or any state securities laws and may not be offered or sold within the United States or to, or for the account or benefit of, ‘U.S. Persons’ (as such term is defined in Regulation S under the U.S. Securities Act) absent such registration or an applicable exemption from the registration requirements of the U.S. Securities Act. This news release does not constitute an offer for sale of securities for sale, nor a solicitation for offers to buy any securities. Any public offering of securities in the United States must be made by means of a prospectus containing detailed information about the company and management, as well as financial statements.

 About Quimbaya

Quimbaya aims to discover gold resources through exploration and acquisition of mining properties in the prolific gold mining districts of Colombia. Managed by an experienced team in the mining sector, Quimbaya is focused on three projects in the regions of Segovia (Tahami Project), Puerto Berrio (Berrio Project), and Abejorral (Maitamac Project), all located in Antioquia Province, Colombia.

Quimbaya Gold Inc.

Follow on X @quimbayagoldinc
Follow on LinkedIn @quimbayagold
Follow on YouTube @quimbayagoldinc
Follow on Instagram @quimbayagoldinc
Follow on Facebook @quimbayagoldinc

Cautionary Statements

 Certain statements contained in this press release constitute ‘forward-looking information’ as that term is defined in applicable Canadian securities legislation. All statements, other than statements of historical fact, included herein are forward-looking information. Generally, but not always, forward-looking statements and information can be identified by the use of forward-looking terminology such as ‘intends’, ‘expects’ or ‘anticipates’, or variations of such words and phrases or statements that certain actions, events or results ‘may’, ‘could’, ‘should’, ‘would’ or ‘occur’. Forward-looking statements herein include statements and information regarding the closing of the Offering, Offering’s intended use of proceeds, any exercise of Warrants, the future plans for the Company, including any expectations of growth or market momentum, future expectations for the gold sector generally, the Colombian gold sector more particularly, or how global or local market trends may affect the Company, intended exploration on any of the Company’s properties and any results thereof, the strength of the Company’s mineral property portfolio, the potential discovery and potential size of the discovery of minerals on any property of the Company’s, including Tahami South, the aims and goals of the Company, and other forward-looking information. Forward-looking information by its nature is based on assumptions and involves known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Quimbaya to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements or information. These assumptions include, but are not limited to, that the Company’s exploration and other activities will proceed as expected. The future outcomes that relate to forward-looking statements may be influenced by many factors, including but not limited to: future planned development and other activities on the Company’s mineral properties; an inability to finance the Company; obtaining required permitting on the Company’s mineral properties in a timely manner; any adverse changes to the planned operations of the Company’s mineral properties; failure by the Company for any reason to undertake expected exploration programs; achieving and maintaining favourable relationships with local communities; mineral exploration results that are poorer or better than expected; prices for gold remaining as expected; currency exchange rates remaining as expected; availability of funds for the Company’s projects; prices for energy inputs, labour, materials, supplies and services (including transportation); no labour-related disruptions; no unplanned delays or interruptions in scheduled construction and production; all necessary permits, licenses and regulatory approvals are received in a timely manner; the Offering proceeds being received as anticipated; all requisite regulatory and stock exchange approvals for the Offering are obtained in a timely fashion; investor participation in the Offering; and the Company’s ability to comply with environmental, health and safety laws. Although Quimbaya’s management believes that the assumptions made and the expectations represented by such information are reasonable, there can be no assurance that the forward-looking information will prove to be accurate. Furthermore, should one or more of the risks, uncertainties or other factors materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described in forward-looking statements or information. Readers are cautioned not to place undue reliance on forward-looking information as there can be no assurance that the plans, intentions or expectations upon which they are placed will occur. Forward-looking information contained in this news release is expressly qualified by this cautionary statement. The forward-looking information contained in this news release represents the expectations of Quimbaya as of the date of this news release and, accordingly, is subject to change after such date. Except as required by law, Quimbaya does not expect to update forward-looking statements and information continually as conditions change.

SOURCE Quimbaya Gold Inc.

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1911 Gold Corporation (TSXV: AUMB,OTC:AUMBF) (OTCQB: AUMF) (FSE: 2KY) (‘1911 Gold’ or the ‘Company’) is pleased to announce that it will be participating in the 51st Annual New Orleans Investment Conference at the Hilton New Orleans Riverside November 2 – 5, 2025. Shaun Heinrichs, President & CEO, will be presenting on Wednesday, November 5th, and is looking forward to networking with investors during the Conference.

The New Orleans Investment Conference gathers some of the world’s brightest and most successful analysts, newsletter writers and investors. This year’s event will highlight all major asset classes, including Gold.

Don’t miss out. Register for the 51st Annual New Orleans Investment Conference by clicking here.

About 1911 Gold Corporation

1911 Gold is a junior developer with a highly prospective, consolidated land package totaling more than 61,647 hectares within and adjacent to the Archean Rice Lake greenstone belt in Manitoba, Canada. The Company also owns the True North mine and mill complex in Bissett, Manitoba. 1911 Gold believes its land package represents a prime exploration opportunity, with the potential to develop a mining district centred on the True North complex.

In addition, the Company holds the Apex project near Snow Lake, Manitoba and the Denton-Keefer project near Timmins, Ontario, and remains focused on advancing organic growth while pursuing accretive acquisition opportunities across North America.

1911 Gold’s True North complex is located within the traditional territory of the Hollow Water First Nation, signatory to Treaty No. 5 (1875-76). 1911 Gold looks forward to maintaining open, co-operative and respectful communication with the Hollow Water First Nation, and all local stakeholders, in order to build mutually beneficial working relationships.

About The New Orleans Investment Conference

The New Orleans Investment Conference is the one place where the world’s most sophisticated investors gather every year to discover new opportunities and strategies, exchange ideas, plan for the coming year and enjoy the camaraderie of like-minded individuals in America’s most fascinating and entertaining city.

Headliners at the New Orleans Conference over the last 50 years have included Lady Margaret Thatcher, former President Gerald Ford, novelist Ayn Rand, General H. Norman Schwarzkopf, Nobel Prize-winning economists Milton Friedman and F.A. Hayek, Dr. Henry Kissinger, Senator Barry Goldwater, Admiral Hyman Rickover, Louis Rukeyser, Sir John Templeton, Lord William Rees-Mogg, Charlton Heston, Jeane Kirkpatrick, Robert Bleiberg, Jack Kemp, William F. Buckley, General Colin Powell, Ron Paul and J. Peter Grace, among hundreds of other notables.

ON BEHALF OF THE BOARD OF DIRECTORS

Shaun Heinrichs
President and CEO

For further information, please contact:

Shaun Heinrichs
Chief Executive Officer

(604) 674-1293
ir@1911gold.com

www.1911gold.com

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/271734

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Trading resumes in:

Company: Quimbaya Gold Inc.

CSE Symbol: QIM

All Issues: Yes

Resumption (ET): 8:15 AM

CIRO can make a decision to impose a temporary suspension (halt) of trading in a security of a publicly-listed company. Trading halts are implemented to ensure a fair and orderly market. CIRO is the national self-regulatory organization which oversees all investment dealers and trading activity on debt and equity marketplaces in Canada.

SOURCE Canadian Investment Regulatory Organization (CIRO) – Halts/Resumptions

Cision View original content: http://www.newswire.ca/en/releases/archive/October2025/24/c1478.html

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Biotech is a dynamic industry that is driving scientific advances and innovation in healthcare. In Canada, the biotech sector is home to companies pursuing cutting-edge therapies and medical technologies.

Read on to learn what’s been driving these Canadian biotech firms.

1. Eupraxia Pharmaceuticals (TSX:EPRX)

Year-on-year gain: 141.23 percent
Market cap: C$410.85 million
Share price: C$8.25

Eupraxia Pharmaceuticals is developing clinical candidates that employ its DiffuSphere technology, which delivers treatments to the targeted tissues.

The company’s candidates are currently EP-104GI for eosinophilic esophagitis and EP-104IAR for knee osteoarthritis, and it is exploring the use of its technology for other active compounds as well.

Eupraxia added EP-104GI to its pipeline through its acquisition of EpiPharma Therapeutics in late 2023. The company has continued to advance the treatment through clinical trials in 2025 and released multiple rounds of positive data from its Phase 1b/2a trial cohorts.

In July, Eupraxia dosed its first patient after advancing its investigation to Phase 2b trials based on safety and efficacy data from the earlier Phase 2a patient cohorts. Top-line results from the Phase 2b study are anticipated in the second half of 2026.

In September, the company shared data from the highest-dose cohort of the still ongoing Phase 1b/2a trials, reporting that the group saw the largest improvements so far.

2. Bright Minds Biosciences (CSE:DRUG)

Year-on-year gain: 103.17 percent
Market cap: C$683.67 million
Share price: C$92.95

Bright Minds Biosciences is developing novel serotonin agonists targeting neurocircuit abnormalities linked to neuropsychiatric disorders and epilepsy, designing next-generation treatments that aim to retain the therapeutic benefits of psychedelics while minimizing side effects.

Its lead candidate, BMB-101, a selective 5-HT2C receptor agonist, has shown encouraging preclinical efficacy by stopping seizures in an epilepsy mouse model, evaluated jointly with Firefly Neuroscience (NASDAQ:AIFF).

The company’s stock surged nearly 1,500 percent in October 2024 following H. Lundbeck’s acquisition announcement of a competitor focused on similar targets. Strengthening its epilepsy expertise, Bright Minds expanded its scientific advisory board in early 2025 by adding five leaders in the field.

Ongoing clinical progress and strategic growth initiatives position Bright Minds as a promising contender in the neuropsychiatric treatment landscape.

3. Hemostemix (TSXV:HEM)

Year-on-year gain: 31.25 percent
Market cap: C$18.40 million
Share price: C$0.11

Hemostemix is a clinical-stage biotech company focused on developing autologous stem cell therapies, meaning the treatments use a patient’s own cells to theoretically enhance safety and efficacy.

Its main product, ACP-01, is an autologous cell therapy designed to promote tissue repair and regeneration in areas affected by diseases, including a range of heart diseases.

The company announced its first advanced sales orders for ACP-01 in Q1 2025 and has been working to expand internationally and attract new investment.

Hemostemix secured the regulatory green light for commercial sales in Florida after the state passed Senate Bill 1768. The bill creates a framework in which healthcare providers can administer stem cell therapies that had not yet been approved by the US Food and Drug Administration (FDA) but meet the bill’s guidelines.

The company now offers commercial ACP-01 treatments for ischemic pain in the state under the name VesCell, with sales forecasted to reach C$22.5 million in 2026. Operational plans target cash flow positivity by Q4 2026, supported by a growing physician network and commercial pipeline.

Additionally, Hemostemix is currently collaborating with Firefly Neuroscience on a Phase 1 clinical trial of ACP-01 for vascular dementia.

4. NervGen (TSXV:NGEN)

Year-on-year gain: 79.92 percent
Market cap: C$300.97 million
Share price: C$4.39

NervGen is a clinical-stage Canadian biotechnology company that focuses on developing innovative treatments to enable the nervous system to repair itself following damage from injury or disease.

The company’s core technology targets a mechanism that hinders nervous system repair. When the nervous system is damaged, chondroitin sulfate proteoglycans (CSPG) form a “scar.” Initially, CSPGs help contain damage, but their long-term interaction with the PTPσ receptor inhibits repair.

NervGen’s lead drug candidate, NVG-291, is designed to relieve these inhibitory effects to promote nervous system repair. It received fast-track designation from the US FDA.

NervGen is advancing NVG-291 in a Phase 1b/2a clinical trial for spinal cord injury (SCI) and reported positive data from the chronic cohort in June.

NVG-300, a newer preclinical candidate, is being evaluated for ischemic stroke and SCI.

Securities Disclosure: I, Meagen Seatter, hold no direct investment interest in any company mentioned in this article.

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