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Phase 1 1 First-In-Human study designed to assess safety   ,   tolerability   , right dose for Phase 2 and early signs of efficacy   of 177Lu-RAD20   2   in individuals with   advanced HER2-positive solid   tumors

Previous clinical proof-of concept data 2 for targeting HER-2 demonstrated the safety and biodistribution of 99mTc-RAD202 in humans

Radiopharm Theranostics (ASX:RAD, ‘Radiopharm’ or the ‘Company’), a clinical-stage biopharmaceutical company focused on developing innovative oncology radiopharmaceuticals for areas of high unmet medical need, today announced the dosing of the first patient in its Phase 1 ‘HEAT’ clinical trial of RAD202, a proprietary nanobody that targets Human Epidermal Growth Factor Receptor 2 (HER2)-positive expression in a wide array of advanced solid tumors.

The open-label Phase 1 ‘HEAT’ clinical trial is a dose escalation trial of 177Lu-RAD202 that is designed to determine the recommended Phase 2 dose and to evaluate the safety and preliminary clinical activity of this novel radiotherapeutic in individuals with HER2-expressing advanced cancers. The study is currently being conducted at clinical centers across Australia.

‘Dosing patients in the HEAT clinical trial marks an important milestone in our transition to a clinical-stage company,’ said Riccardo Canevari, CEO and Managing Director of Radiopharm Theranostics. ‘Despite progressive improvements in the management of metastatic HER2-positive disease, the majority of patients experience disease progression on current standard of care and require further therapeutic options. The dosing of the first patient in the ‘HEAT’ trial represents a significant step toward achieving RAD202’s potential to address an unmet need for HER2-positive metastatic patients who are progressing or unable to tolerate current treatment options. With RAD202, we hope to provide an option that can meaningfully improve clinical outcomes for HER2-positive patients, while preserving their quality of life.’

HER2 is overexpressed in breast cancer as well as several other solid tumors and represents a validated target in oncology. RAD202 is a proprietary single domain antibody that targets HER2. Ten HER2-positive breast cancer patients previously dosed in a Phase 1 diagnostic study of RAD202 demonstrated clinical proof-of concept as well as the safety and biodistribution of RAD202, validating its potential for the treatment of advanced HER2-expressing cancers 2 . Preclinical findings 3 examining the therapeutic effect in HER2-positive xenografts were also recently reported with 177Lu-RAD202. Collectively, these data further justify first in humans dose finding studies.

‘It is a privilege to be the first centre to administer 177Lu-RAD202, targeting HER2-positive tumors in this Phase 1 clinical trial (HEAT).’ said Dr Aviral Singh, Clinical Head of Theranostics and Nuclear Medicine at St John of God Murdoch Hospital. ‘This opens the possibility of novel therapeutic avenues for patients with aggressive tumor types, including breast, ovarian, gastric, pancreatic, bladder, and several other cancers. With the trust put in us by Radiopharm, we look forward to a successful trial with beneficial outcomes for our patients.’

About Radiopharm Theranostics

Radiopharm Theranostics is a clinical stage radiotherapeutics company developing a world-class platform of innovative radiopharmaceutical products for diagnostic and therapeutic applications in areas of high unmet medical need. Radiopharm is listed on ASX (RAD) and on NASDAQ (RADX). The company has a pipeline of distinct and highly differentiated platform technologies spanning peptides, small molecules and monoclonal antibodies for use in cancer. The clinical program includes one Phase 2 and three Phase 1 trials in a variety of solid tumor cancers including lung, breast, and brain metastases. Learn more at radiopharmtheranostics.com .

Authorised on behalf of the Radiopharm Theranostics board of directors by Chairman Paul Hopper.

For more information:
Riccardo Canevari
CEO & Managing Director
P: +1 862 309 0293
E: rc@radiopharmtheranostics.com

Anne Marie Fields
Precision AQ (Formerly Stern IR)
E: annemarie.fields@precisionaq.com

Paul Hopper
Executive Chairman
P: +61 406 671 515
E: paulhopper@lifescienceportfolio.com

Media
Matt Wright
NWR Communications
P: +61 451 896 420
E: matt@nwrcommunications.com.au

________________________________

1 clinicaltrials.gov/study/NCT06824155
2 Zhao et al, Molecular Pharmaceutics 2021 18 (9), 3616-3622
3 Altunay B. et al, EP-0136, Eur J Nucl Med Mol Imaging (2024) 51 (Suppl 1): S1–S1026. DOI: 10.1007/s00259-024-06838-z

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LaFleur Minerals Inc. (CSE: LFLR) (OTCQB: LFLRF) (FSE: 3WK0) (‘LaFleur Minerals’ or the ‘Company’) is pleased to provide the results of its recent exploration programs, including an update on its diamond drilling and bulk sampling plans at its district-scale Swanson Gold Project (‘Swanson’), positioned in the prolific Abitibi Gold Belt (Figure 1). The Company is also fast-tracking the restart of its 100%-owned, 750 tonne per day (‘tpd’) Beacon Gold Mill (‘Beacon’) in Val-d’Or, Québec, and has received significant interest from several groups for the purpose of financing the mill restart as well as to offtake material and support the ramp-up to full production with the goal to be generating cash flow by early 2026.

The interest received to date is a strong vote of confidence in the quality and potential of the Beacon Mill, as a foundational and keystone asset of the Company, its strategic positioning in one of the world’s richest and most well-endowed mineralized mining regions with numerous surrounding gold deposits suitable for bulk sampling, which would be ideal sources of mineralized material to complement this transformational next phase of development for LaFleur Minerals.

HIGHLIGHTS

  • Immediate plans to complete at least 5,000 metres of diamond drilling at Swanson starting in June using existing flow-through (FT) funds, with over 50 promising drilling targets identified, among the other highly prospective Bartec, Jolin, and Marimac gold targets. A drilling contractor has been selected with drilling permits expected by early June.
  • Geological and engineering planning continues for a large bulk sampling program at the Swanson mining lease with an updated Scoping Study and mine plan to be submitted to Québec government for approval. The plan includes the extraction of an up to 100,000 tonne surface bulk sample at Swanson for processing at the Beacon Mill once it is in full production (anticipated by early 2026).
  • The Company is in advanced discussions with several institutional and private equity groups, as well as exploring non-dilutive funding options with several commodity trading and debt financing firms to fund Beacon Mill’s restart. The Company’s goal is to be fully-funded, complete upgrades, and become fully operational by early 2026.

Paul Ténière, CEO of LaFleur Minerals, commented, ‘We are very excited to commence our summer diamond drilling program to test the regional exploration targets identified from our recent exploration programs at Swanson. These drilling targets are based on careful and well executed geological, geochemical, and geophysical programs by our technical team. Swanson is a large regional exploration project with numerous gold showings and the upcoming diamond drilling program will focus on showings that have the potential to host significant large gold deposits.

‘In addition, we are forging ahead with the permitting process for the Swanson bulk sample and funding the restart of the Beacon Gold Mill to generate cash flow as quickly as possible, with the longer-term vision of funding additional project acquisitions and expanding LaFleur Minerals from a small to intermediate gold producer in the Val-d’Or region. With a restart cost that is so low, LaFleur Minerals has the ability to move towards commercial production and profitability near term, achieving an outstanding milestone in an exceptionally short period of time thanks to the methodical work of the Company’s technical and management team, largely supported by the increasingly attractive precious metals market.’

PETER ESPIG JOINS LaFleur Minerals AS STRATEGIC ADVISOR

The Company is also pleased to announce that Peter Espig has joined the Company as a Strategic Advisor and Consultant focused on the capital markets and assisting with the funding of the Swanson and Beacon Gold Mill projects. Mr. Espig also brings substantial experience in managing the funding, construction, ramp up, and operation of gold and silver milling and processing facilities in Canada.

Mr. Espig served as Vice-President at Goldman Sachs Japan in both the Principal Finance and Securitization Group and the Asia Special Situations Group, where his team participated in more than $10 billion in structured deals, capital raises, and cross-border transactions. Prior to Goldman Sachs, he was Vice-President at Olympus Capital, a New York-based private equity firm, where he focused on corporate restructurings, investment analysis, and international financing negotiations. He also played a pioneering role in some of the earliest SPAC transactions, totaling over US$1.2 billion, and brings deep experience in disciplined capital deployment and turnaround execution.

Since 2013, Mr. Espig has served as President and CEO of Nicola Mining Inc. and is a board member of ESGold Corp and First Lithium Minerals. Mr. Espig holds a Bachelor of Arts from the University of British Columbia and an MBA from Columbia Business School, where he was a Chazen International Scholar. He has served on various public boards and was recognized among Industry Era’s ‘Top 10 Admired Leaders’ in 2023.

GRANT OF STOCK OPTIONS

The Company also announces that it has granted incentive stock options (‘Options‘) to management and consultants of the Company to acquire an aggregate of 1,250,000 common shares at $0.20 per share, for a period of three years. These Options have been granted in accordance with the Company’s stock option plan.

SITE VISIT AND MANAGEMENT UPDATE CALL

The Company plans to coordinate a site visit of its Beacon Mill in June 2025 for any prospective investors, shareholders, and analysts. The Company will host a management update call for investors on Thursday June 5, 2025, at 10:00 a.m. Pacific Time / 1:00 p.m. Eastern Time. The call will be accessible via the Zoom platform, by video conference and by telephone, and participants should use the following information to join the call:

Please click the link below to join the LaFleur video call:
https://us06web.zoom.us/j/89960363165?pwd=0a0hXT9yEvAogURcX4EO0VRwuU3LaZ.1
Webinar ID: 899 6036 3165
Passcode: 888888

Or join via telephone:
United States: +1 646 931 3860
Canada: +1 647 374 4685
United Kingdom: +44 330 088 5830
Webinar ID: 864 5330 0862
More international numbers are available on the following link: https://us06web.zoom.us/u/keDxuREffH

SUMMARY OF RECENT SWANSON EXPLORATION RESULTS

LaFleur Minerals recently received the final reports for its 2024 prospecting and reconnaissance mapping, soil sampling program, and IP survey. This exploration data has been incorporated into the Company’s geological and GIS database, along with the regional high-resolution magnetic and VLF-EM survey completed earlier in 2024, which has been used to develop priority drill targets to be tested this summer.

Geological Reconnaissance Mapping and Prospecting

Geological reconnaissance mapping and prospecting was carried out in September 2024 by IOS Géosciences Inc. (‘IOS‘). The work, including the collection of 144 samples that were sent to the laboratory, focused on key deposits, showings, and mineralized outcrops, compiled from the literature (Figure 2). Out of the 25 mineral occurrences reported since 1926 at Swanson, 10 were selected to represent the focus of interest. The Swanson, Jolin, Barautte VII, and Jackson showings display characteristics that are indicative of orogenic-gold-type mineralization and magmatic-hydrothermal-type mineralization. The reported results included the discovery of new highly prospective lithologies, hydrothermal alterations, sulphide mineralization, and corresponding gold grades. Best gold grades from grab samples included:

  • 11.71 g/t Au located 425 m SW of the Jolin deposit
  • 4.59 g/t Au located 140 m south of the Barautte VII showing
  • 4.51 g/t Au and 3.78 g/t Au in the area of the Jackson showing
  • 2.98 g/t Au in the area of the Bartec showing

Please note: Grab samples are selective by nature and may not be representative of the overall mineralization on the Swanson Project. While they are useful for identifying areas of interest and guiding further exploration, they should not be relied upon as an indicator of the average grade or extent of mineralization.

Soil Survey

A soil survey was also carried out in September 2024 by IOS. The objective of the 2024 soil sampling program was to assess Swanson’s potential to contain unknown blind gold occurrences by using the dispersion of geochemical signals in surficial materials. The survey included 315 sampling sites distributed along 8 grids according to the local quaternary geology, aerial photos and LiDAR images (Figure 3). The survey was designed to test the efficiency of the method and targeted areas with known occurrences. Lines were oriented perpendicular to the geophysical anomaly and/or geological features.

The gold-enriched soil samples located to the SW of the Damascus showing were found to be associated with an untested IP anomaly. The soil samples near the Jackson showing and Bartec deposit, and samples approximately 750 m SSW of the Swanson deposit and on two lines located 300 to 550 m south of the Jolin deposit, all show gold-enrichment.

Please note: Soil sampling surveys are not definitive, and the results are still at an early stage of interpretation, with no guarantee of a mineral discovery.

Induced Polarization Geophysics Survey

An Induced Polarization (IP) survey was carried out at Swanson between January and April 2024 by TMC Geophysics. The survey consisted of 120.4 line-km of IP using the pole-dipole electrode array with a configuration of a=25 m, n=1 to 16 over two distinct grids, namely Jolin and Bartec (Figure 4).

A total of 64 IP axes indicative of the most obvious anomalies have been identified on both prospects. These include:

  • A first group of IP axes characterize some of the strongest and more continuous polarizable anomalies. The associated polarizable sources are typically correlated with slight to strong decreases in resistivity or included within the confines of thin conductive beds/horizons. According to the regional geology, this type of signature is, at least partially, of the lithological type and indicative of the known pyrite and graphite rich units/lithologies of both prospects. On the other hand, one cannot exclude to see these units themselves locally enriched in poly-metallic mineralization (+/- Au). Some other axes of this group may also directly emphasize polymetallic mineralization developed along broad shear zones, or altered geological contacts favored by the upwelling of hydrothermal fluids.
  • The second group of IP axes feature weaker and less continuous polarizable anomalies that are partially correlated with an increase in resistivity. They all have the potential to indicate the presence of gold-rich mineralization associated with disseminated sulphide remobilized along a fault or altered and silicified band of rocks (+/- quartz/carbonate veining).

As for the follow-up work, 7 IP axes have been selected to be drill tested on the Jolin grid, and 4 others on the Bartec grid.

2025 SWANSON DIAMOND DRILLING PROGRAM PLANS

Following the regional compilation and high-resolution magnetics and VLF-EM over the entire Swanson Gold Project, along with the recent encouraging results of the reconnaissance mapping and prospecting, soil sampling and IP survey discussed above, LaFleur Minerals will move forward with its regional drilling program.

Approximately 50 drill targets have currently been identified based on the compilation and recent field work. The targets are located regionally in the Swanson, Jolin, Bartec and Marimac regions (Figure 5). Phase I of the diamond drill program will include 20 exploration drill holes totalling at least 5,000 m of diamond drilling.

LaFleur Minerals is pleased to announce that it has signed a drilling contract with Forage Rouillier Drilling of Amos, Québec and is expecting to start drilling at Swanson in early- to mid-June 2025 once drilling permits have been received from the Québec government.

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Figure 1: Swanson Gold Project (including the Swanson Deposit) located 50 km from the Beacon Gold Mill

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Figure 2: Geological Reconnaissance – Sample locations and anomalous results

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Figure 3: Soil Samples – Anomalous Results

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Figure 4: Lines Completed by IP Survey

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Figure 5: Swanson drilling target regions and proposed 2025 drill holes (in purple)

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SAMPLE PREPARATION, LABORATORY ANALYSIS, AND QA/QC SUMMARY

Rock (Grab) Samples

All rock (grab) samples collected by IOS during the program were securely transported to Activation Laboratories (Actlabs) in Ancaster, Ontario, an ISO/IEC 17025-accredited laboratory. Grab sample sizes vary by rock collected but varies from 1 kg to 3 kg. Actlabs is independent of LaFleur Minerals. Sample preparation included crushing, splitting, and pulverizing to 95% passing 105 microns. Gold analysis was performed using fire assay with an inductively coupled plasma mass spectrometry (1A2-ICPMS) finish. A multi-element analysis (63 elements) was also done on the samples using an Aqua regia digestion / ICP-MS (Ultratrace-1). Borate fusion with XRF finishing was carried out for samples exceeding the limit for tungsten. The Company follows industry-standard QA/QC protocols, including the insertion of certified reference materials, blanks, and duplicates to ensure the accuracy and precision of the results.

Soil Samples

Soil samples were collected by IOS at a depth of 10 cm to 25 cm below the base of the Ah horizon with an average sample size approximately 1 kg. As such, the sample can be composed of either the Ae, B or C horizon, or be a composite of these horizons depending on the soil profile. Sampling was done using a shovel or an auger depending on the environment and depth necessary to sample the correct horizon.

Samples were securely transported back to IOS facilities in Saguenay, Québec by the field crew. The samples were prepared in the IOS laboratory for environmental parameter measurements (e.g. pH, Eh, etc.) and handheld XRF analysis. Upon reception of the samples by the IOS lab and prior to any preparation, a 20 gram aliquot was taken to perform measurements that need to be conducted on the raw material. The remaining material was dedicated to preparation for loss on ignition (LOI) and chemical analyses. Environmental parameters such as pH, δpH, Eh and TDS (Total Dissolved Solids, i.e., conductivity) were measured on saturated paste according to standard procedures.

Samples were then securely courier shipped to ALS Minerals in Val-d’Or for final preparation before the final shipping to ALS Minerals in Vancouver for Ionic LeachTM. ALS Minerals is independent of LaFleur Minerals. Sample material dedicated for chemical analysis were air dried and sieved at

The anomaly thresholds were determined by IOS using a probabilistic approach. In that the assays results are first transformed into logarithmic data. The Z-score is then calculated for each element of each sample. This significantly limits the range of values and enables the use of a normal distribution for the probability modelling. The anomaly threshold for an element is determined by the difference between the sample’s Z-score and the expected Z-score for a log-normal population with an average of 0 and a standard deviation of 1, which represents the regional background as confirmed by the analysis of IOS’s large database. Any sample deviated from that regional trend is likely related to an anomalous population.

SWANSON GOLD PROJECT SUMMARY

The Swanson Gold Project is approximately 16,600 hectares in size and includes several prospects rich in gold and critical metals previously held by Monarch Mining, Abcourt Mines, and Globex Mining. The Swanson Gold Project covers major structural breaks that hosts the Swanson Gold Deposit, and Bartec, and Jolin gold targets and numerous other showings which make up the Swanson Gold Project. The Swanson Gold Project has had in excess of 36,000 metres of historical diamond drilling, is easily accessible by road with a rail line running through the property, allowing direct access to the Beacon Gold Mill, which further enhances its development potential.

The Swanson Gold Deposit hosts:

  • Indicated Mineral Resource Estimate:
    • 2,113,000 t with an average grade of 1.8 g/t gold, containing 123,400 oz of gold.
  • Inferred Mineral Resource Estimate:
    • 872,000 t with an average grade of 2.3 g/t gold, containing 64,500 oz of gold.

(MRE source: NI 43-101 technical report, effective September 17, 2024, filed on the Company’s SEDAR+ profile)

    (Source: GESTIM -1996, GM62629 – historical estimate not compliant with NI 43-101)

      (Source: GESTIM – DV 87-01 – historical estimate not compliant NI 43-101)

      QUALIFIED PERSON STATEMENT AND DATA VERIFICATION

      All scientific and technical information in this news release has been prepared and approved by Louis Martin, P.Geo. (OGQ), Exploration Manager and Technical Advisor of the Company and considered a Qualified Person for the purposes of NI 43-101. Mr. Martin has reviewed and verified the rock and soil sampling results and certified analytical data underlying the technical information disclosed. Mr. Martin noted no errors or omissions during the data verification process and the Company’s management have also verified the technical information disclosed. The Company and Mr. Martin do not recognize any factors of sampling or recovery that could materially affect the accuracy or reliability of the assay data and exploration results disclosed in this news release.

      About LaFleur Minerals Inc.

      LaFleur Minerals Inc. (CSE: LFLR) (OTCQB: LFLRF) (FSE: 3WK0) is focused on the development of district-scale gold projects in the Abitibi Gold Belt near Val-d’Or, Québec. Our mission is to advance mining projects with a laser focus on our resource-stage Swanson Gold Project and the Beacon Gold Mill, which have significant potential to deliver long-term value. The Swanson Gold Project is approximately 16,600 hectares (166 km2) in size and includes several prospects rich in gold and critical metals previously held by Monarch Mining, Abcourt Mines, and Globex Mining. LaFleur has recently consolidated a large land package along a major structural break that hosts the Swanson, Bartec, and Jolin gold deposits and several other showings which make up the Swanson Gold Project. The Swanson Gold Project is easily accessible by road with a rail line running through the property allowing direct access to several nearby gold mills, further enhancing its development potential. LaFleur Minerals’ fully-refurbished and permitted Beacon Gold Mill is capable of processing over 750 tonnes per day and is being considered for processing mineralized material at Swanson and for custom milling operations for other nearby gold projects.

      ON BEHALF OF LaFleur Minerals INC.
      Paul Ténière, M.Sc., P.Geo.
      Chief Executive Officer
      E: info@lafleurminerals.com
      LaFleur Minerals Inc.
      1500-1055 West Georgia Street
      Vancouver, BC V6E 4N7

      Neither the Canadian Securities Exchange nor its Regulation Services Provider accepts responsibility for the adequacy or accuracy of this news release.

      Cautionary Statement Regarding ‘Forward-Looking’ Information

      This news release includes certain statements that may be deemed ‘forward-looking statements’. All statements in this new release, other than statements of historical facts, that address events or developments that the Company expects to occur, are forward-looking statements. Forward-looking statements are statements that are not historical facts and are generally, but not always, identified by the words ‘expects’, ‘plans’, ‘anticipates’, ‘believes’, ‘intends’, ‘estimates’, ‘projects’, ‘potential’ and similar expressions, or that events or conditions ‘will’, ‘would’, ‘may’, ‘could’ or ‘should’ occur. Forward-looking statements in this news release include, without limitation, statements related to the use of proceeds from the Offering. Although the Company believes the expectations expressed in such forward-looking statements are based on reasonable assumptions, such statements are not guarantees of future performance and actual results may differ materially from those in the forward-looking statements. Factors that could cause the actual results to differ materially from those in forward-looking statements include market prices, continued availability of capital and financing, and general economic, market or business conditions. Investors are cautioned that any such statements are not guarantees of future performance and actual results or developments may differ materially from those projected in the forward-looking statements. Forward-looking statements are based on the beliefs, estimates and opinions of the Company’s management on the date the statements are made. Except as required by applicable securities laws, the Company undertakes no obligation to update these forward-looking statements in the event that management’s beliefs, estimates or opinions, or other factors, should change.

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      triumph gold Corp. (TSXV: TIG) (OTC Pink: TIGCF) (FSE: 8N6) (‘triumph gold’ or the ‘Company’) is pleased to announce the acquisition of the Coyote Knoll Silver (Ag Gold (Au) Property, located in central Utah, approximately 40 km southwest of the prolific Tintic Mining District (Figure 1).

      triumph gold has entered into an agreement to purchase the Coyote Knoll Silver-Gold property for the sum of $150,000USD and the issuance of one million common shares of the Company. Prior to one year from the date of purchase, one million common shares shall be issued to the seller; prior to two years from the date of purchase one million common shares will be issued; prior to three years from the date of purchase one million common shares shall be issued to the seller. Before four years from the date of purchase a three million dollar payment in cash or shares will be made to the seller.

      Highlights:

      • Approximately 2,600 metres of RC drilling have been completed, highlighted by 1,350.36 g/t Ag and 3.86 g/t Au over 3.00 metres in ATC-C6 (Table 1 & 2 and Figure 2)NI 43-101 Disclosure 1.
      • Historical rock samples returned silver and gold values, up to 6,730.00 g/t Ag and 23.30 g/t Au (Table 2)NI 43-101 Disclosure 2.
      • Two east-west parallel veins were identified through reverse circulation (RC) drilling and exposed during mining.
      • Recent surface sampling confirmed silver and gold mineralization, with grab samples returning up to 795 g/t Ag and 1.58 g/t Au (Table 4)NI 43-101 Disclosure 2.
      • In 2012, a 12-ton representative bulk sample returned an average grade of 43.60 oz/ton silver and 0.13 oz/ton goldNI 43-101 Disclosure 3.
      • In 1998 Phoenix Gold Resources shipped Coyote Knoll ore to Clifton Mining’s mill at Gold Hill where a 1,000 ounces of silver doré was producedNI 43-101 Disclosure 4.
      • A second mineralized structure, trending northwest-southeast, has been identified through surface sampling and RC drilling.

      John Anderson, Chairman and CEO of triumph gold, stated:

      ‘The Coyote Knoll acquisition represents an exciting addition to our portfolio. Located in a mining-friendly and historically significant region, the property demonstrates high-grade silver mineralization and favorable geological features, similar to those found in the Tintic Mining District. With the confirmation of epithermal silver-gold mineralization and the potential for further discovery, we look forward to advancing exploration at Coyote Knoll.’

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      Figure 1. Coyote Knoll property location map.

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      Figure 2. Coyote Knoll drill and sample highlights.

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      Location and Geological Overview:

      Coyote Knoll is located in central Utah, approximately 85 km south of Bingham Canyon Cu-Mo-Au Porphyry deposit and 40 km southwest of the city of Eureka. Eureka is historically associated with the Tintic Mining District, which has been a major producer of gold, silver, lead, and zinc from both epithermal and Carbonate Replacement Deposits (CRD). The Tintic District is known for its productive mining history and the potential for undiscovered porphyry systems.

      Coyote Knoll was discovered in 1988, with subsequent exploration activities including mapping, trenching, rock sampling, and induced polarization and magnetic geophysical surveys. Follow-up work also included near-surface Reverse Circulation RC-drilling, totaling 2,606.96 metres across 33 drill holes. Highlights from historical drilling are summarized in Table 1 & 2, and surface samples are highlighted in Table 3. A 12-ton representative bulk sample was also mined from a shallow open pit, centered over the east-west (70°) trending mineralized structure. Silver and gold epithermal mineralization was exposed over approximately 60 metres within the open pit and has been delineated for 1.5 km through surface trenching, sampling, and shallow RC drilling (Figure 2).

      Table 1. Historic RC drilling composite highlights

      Hole-ID From (m) To (m) Interval (m) Ag g/t Au g/t
      AT1-C6 54.10 57.10 3.00 1350.36 3.86
      CK-10 68.60 74.70 6.10 114.84 0.12
      AT1-C5 49.80 54.30 4.50 99.37 0.40
      CK-1 27.40 32.00 4.60 68.89 0.09
      CK-10 51.80 54.90 3.10 67.81 0.38
      CK-10 61.00 64.00 3.00 38.50 0.08
      CK-2 36.60 39.60 3.00 60.00 0.18
      CK-2 53.30 57.90 4.60 39.04 0.09
      CK-15 21.30 24.40 3.10 40.39 0.07

       

      NI 43-101 Disclosure 1.

      *Composites grades were calculated using Datashed software with >25 g/t Ag cutoff and

      Table 2. Historical drill attributes for Table 1 highlights.

      Hole-ID Easting Northing Elevation (m) Depth (m) Azimuth Dip
      AT1-C5 367,889 4,408,432 1,622 76 -90
      AT1-C6 367,897 4,408,436 1,621 75 -90
      CK-1 367,904 4,408,411 1,613 80 170 -60
      CK-2 367,910 4,408,421 1,616 87 -90
      CK-10 367,951 4,408,442 1,624 110 -90

       

      NI 43-101 Disclosure 1.

      Two additional historical drill holes (CK-141. and CK-232.) have previously been reported to contain high gold values and are in proximity to the open pit. CK-14 has an intercept of 8.19g/t Au and 1,060g/t Ag over 1.52 m from 9.14 m downhole. CK-23 has an intercept of 2g/t Au and 814g/t Ag over 1.52 m from 45.72 m downhole.

      1. Freeport-McMoRan Gold Company, 1989-1990; Reverse Circulation Drill Hole CK-14; from NI 43-101 Technical Report on the Coyote Mine Project Juab County, Utah, USA, Arthur J. Mendenhall.
      2. Freeport-McMoRan Gold Company, 1989-1990; Reverse Circulation Drill Hole CK-23; from NI 43-101 Technical Report on the Coyote Mine Project Juab County, Utah, USA, Arthur J. Mendenhall.

      Table 3. Historic rock sample highlights

      Sample-ID Easting Northing Ag g/t Au g/t
      CK-5 367,870 4,408,430 6730.00 23.30
      54359 367,924 4,408,270 6687.08 26.37
      CK-6 367,870 4,408,430 6490.00 13.10
      CKRX-0001 367,928 4,408,377 5570.00 12.25
      CK-3 367,870 4,408,430 2270.00 9.63
      48396 367,884 4,408,389 1673.83 7.30
      48395 367,933 4,408,423 1638.86 0.51
      48382 367,927 4,408,360 1086.86 6.03
      CK-4 367,870 4,408,430 979.00 14.05
      48380 367,911 4,408,333 600.69 1.03
      54354 367,858 4,408,379 370.97 0.31
      56251 367,411 4,408,309 172.00 173.14
      CKRX-0027 368,645 4,408,585 3.38 0.02

       

      NI 43-101 Disclosure 2.

      While Coyote Knoll is approximately 40 km southwest of the Tintic District the geological setting at Coyote Knoll exhibits similarities to the Tintic Mining District. Where precious metal epithermal veins at the Trixie Mine are formed within faulted quartzites and the Burgin and Tintic Standard mines are hosted in carbonate-rich stratigraphy forming CRD. During the March site visit, the Company also toured the high-grade Trixie Gold Mine to gain further insight into the regional geological setting of the Tintic Mining District. At Coyote Knoll, epithermal mineralization is located along the margin a large volcanic caldera hosting a granitic center. Veining crosscuts quartzite, carbonate-rich stratigraphy and volcanic flows. This provides an encouraging framework for the exploration of both epithermal veins and potential carbonate replacement mineralization at Coyote Knoll.

      Fieldwork conducted during a March 2025 site visit confirmed the presence of epithermal-style mineralization with key geological features including:

      • Silica-flooded pebble clastic fault breccia (pebble dyke), jasperoid, and chalcedony vein infill hosted within faulted quartzite.
      • Mineralization consisted of native silver and silver sulphide ‘sulfosalt’ minerals.
      • Secondary northwest-trending epithermal veining represented by quartz-carbonate and jasperoid infill. This trend contains anomalous silver and elevated pathfinder elements such as arsenic (As), copper (Cu), lead (Pb), antimony (Sb), and zinc (Zn) (Table 4).

      Table 4. Coyote Knoll grab sample results (March 2025 site visit)

      Sample-ID Easting Northing Ag
      g/t
      Au
      g/t
      As
      ppm
      Cu
      ppm
      Pb
      ppm
      Sb
      ppm
      Zn
      ppm
      A001051 367,537 4,408,331 1.23 25.40 8.90 11.80 0.85 4.00
      A001052 367,905 4,408,383 0.22 364.00 9.60 4.50 2.27 47.00
      A001053 367,874 4,408,395 0.31 207.00 21.50 11.50 2.61 147.00
      A001054 367,839 4,408,395 795.00 1.58 61.40 68.40 177.50 67.60 24.00
      A001055 367,787 4,408,386 20.70 0.06 431.00 45.30 31.70 7.98 122.00
      A001056 368,438 4,408,853 1.23 29.70 6.60 9.60 2.85 8.00
      A001057 368,424 4,408,894 0.25 11.40 19.40 1.80 0.31 12.00
      A001061 367,891 4,408,372 1.86 381.00 82.80 38.70 19.65 36.00
      A001062 367,898 4,408,367 1.87 66.30 27.40 22.40 1.00 7.00

       

      NI 43-101 Disclosure 2.

      National Instrument 43-101 Disclosure

      The technical content of this news release has been reviewed and approved by triumph gold’s Principal Geologist Marty Henning, P.Geo., a ‘Qualified Person’ as defined in National Instrument 43-101 – Standards of Disclosure for Mineral Projects of the Canadian Securities Administrators (‘NI 43-101’). He verified the data collected during the March 2025 site visit, including sampling, analytical and test data, and the underlying technical information in this news release.

      The historical data presented in this release has not been verified for accuracy and reliability with the use of current quality assurance, quality control, or chain of custody standards current with NI 43-101 best practices. See the following disclaimers for additional details.

      1. The Company has not done sufficient work to classify the historical drilling information as current to NI 43-101 and is not treating the historical drilling disclosure as a current mineral estimate. Historical drilling database has not been verified for accuracy or quality. The reported historical values in this release require verification through additional exploration drilling, twinned holes will be used to verify style, grade and widths of mineralization.
      2. Grab samples are from select surface material and may not represent true underlying mineralization and drilling is required to confirm mineralization width and grade continuity below surface. Additional sampling is required to verify historical rock sample database.
      3. The 12-ton bulk sample reported in 2012 has not been verified for accuracy or quality control and therefore the reported tonnage and grades are not considered a 43-101 mineral resource estimate or a pre-feasibility study. Additional exploration drilling and metallurgical studies are required to verify tonnage and concentrations of silver and gold contained beneath the mined-out area. The bulk sample values are provided to illustrate the presence of surface mineralization.
      4. The 1,000 ounces of silver doré, produced in 1998 reported by Phoenix Gold Resources has not been verified. This information is not considered a mineral resource estimate as there were no reported head grades or tonnage provided. Additional drilling and metallurgical studies are required to verify width, strike and plunge of the surface mineralization reported from the open pit operation at Coyote Knoll. This bulk sample information is provided to illustrate the presence of surface mineralization.

      Rock samples collected during the site were located using a handheld GPS, material was sealed in heavy poly ore sample bags with a representative sample retained for future inspection. Samples were placed into a 5-gal pail and shipped to ALS Vancouver for analyses. Samples were crushed, split and pulverized using PREP-31 specifications and analyses was completed using ME-GRA22 for Ag and Au as well as ME-MS41 for a multielement output utilizing an aqua regia digest, over limit elements (Ag, Cu and Pb) were analyzed using OG46.

      About triumph gold Corp.

      triumph gold is a Canadian based, growth-oriented exploration and development company with a district scale land package in mining friendly Yukon. Led by an experienced management and technical team, The Company is focused on actively advancing their flagship Freegold Mountain Project using multidiscipline exploration and evaluation techniques. The Company acknowledges the Freegold Mountain, Tad Toro and Big Creek properties are situated within the traditional territory of the Little Salmon Carmack and Selkirk Nations. triumph gold is committed to ongoing engagement with local communities through communication, environmental stewardship, and local employment.

      The road-accessible Freegold Mountain Project, located in the Dawson Range Au-Cu Belt, is host to three NI 43-101 Mineral Deposits (Nucleus, Revenue, and Tinta Hill). The Project is 200 square kilometers and covers an extensive section of the Big Creek Fault Zone, a structure directly related to epithermal gold and silver mineralization as well as gold-rich porphyry copper mineralization.

      The Company owns 100% of the Big Creek and Tad/Toro gold-silver-copper properties situated along strike of the Freegold Mountain Project within the Dawson Range.

      The Company also owns 100% of the Andalusite Peak copper-gold property, situated 36 km southeast of Dease Lake within the Stikine Range in British Columbia. The Company acknowledges the Andalusite Peak property project is situated within the traditional territory of the Tahltan Nation. triumph gold is committed to ongoing engagement with local communities through communication, environmental stewardship, and local employment.

      On behalf of the Board of Directors,

      Signed ‘John Anderson’

      John Anderson, Executive Chairman

      For further information about triumph gold, please contact:

      John Anderson, Executive Chairman
      triumph gold Corp.
      (604) 218-7400
      janderson@triumphgoldcorp.com

      Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

      This news release contains forward-looking information, which involves known and unknown risks, uncertainties and other factors that may cause actual events to differ materially from current expectation. Important factors – including the availability of funds, the results of financing efforts, the completion of due diligence and the results of exploration activities – that could cause actual results to differ materially from the Company’s expectations are disclosed in the Company’s documents filed from time to time on SEDAR+ (see www.sedarplus.ca). Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. The company disclaims any intention or obligation, except to the extent required by law, to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise

      To view the source version of this press release, please visit https://www.newsfilecorp.com/release/254408

      News Provided by Newsfile via QuoteMedia

      This post appeared first on investingnews.com

      Cryptocurrency investors have experienced a real rollercoaster in the last few years — the likes of Bitcoin, Ethereum and Ripple have had incredible highs and crashes, and investors have seen big gains and losses in tandem.

      Despite that volatility, many market participants are still interested in how to enter and make money in the cryptocurrency sector. But depending on how you look at it, perhaps the bigger story is blockchain technology, the backbone of crypto.

      A blockchain is a digitized and decentralized public ledger that has many applications in different industries as a way to provide transparency. In the crypto realm, blockchain is used to record all cryptocurrency transactions, and it is also the mechanism through which some digital currencies like Bitcoin are “mined” into existence.

      The technology has become a popular investment in its own right for savvy investors. Not only are there many blockchain-focused tech stocks, large companies like Meta Platforms (NASDAQ:META), IBM (NYSE:IBM) and Microsoft (NASDAQ:MSFT) have invested in blockchain technology. These corporations see the potential for blockchain to play a role in sectors such as driverless vehicles, food safety and fintech.

      For those new to the blockchain space, deciding on a specific company to invest in may seem overwhelming, especially with the current market uncertainty around cryptocurrency price movements.

      That’s where exchange-traded funds (ETFs) come in. What are blockchain ETFs? In simple terms, ETFs are marketable securities that track an index, a commodity, bonds or a basket of assets like an index fund. ETFs trade like a stock on an exchange, and each ETF owns its underlying assets, dividing them up into shares that are available to investors.

      For those interested in diving into the blockchain investing market using ETFs, the list below includes the top five best blockchain ETFs by total assets as per information on ETF.com as of May 28, 2025.

      1. Amplify Transformational Data Sharing ETF (ARCA:BLOK)

      Total assets: US$893 million

      The Amplify Transformational Data Sharing ETF launched in January 2018. This fund invests in diverse areas of the blockchain sector, such as companies with blockchain platforms, companies developing blockchain applications and blockchain mining companies.

      Amplify is an actively managed blockchain ETF, which makes it stand out against the other ETFs on this list. It has 51 holdings with an expense ratio of 0.73 percent. The Amplify Transformational Data Sharing ETF’s top holdings include Metaplanet (OTCQX:MTPLF,TSE:3350), Robinhood Markets (NASDAQ:HOOD) and Galaxy Digital (TSX:GLXY,NASDAQ:GLXY).

      2. VanEck Digital Transformation ETF (NASDAQ:DAPP)

      Total assets: US$182 million

      The VanEck Digital Transformation ETF launched in April of 2021 and tracks the price and yield performance of the MVIS Global Digital Assets Equity Index. The index is tied to the performance of companies whose revenues are at least 50 percent accrued from the digital assets economy, including exchanges, crypto miners and other crypto infrastructure companies.

      DAPP has 22 holdings, 63 percent of which are headquartered within the United States, and has an expense ratio of 0.51 percent. Its top holdings include Strategy (NYSE:MSTR), Coinbase Global (NASDAQ:COIN) and Metaplanet.

      3. Fidelity Crypto Industry and Digital Payments ETF (NASDAQ:FDIG)

      Total assets: US$170 million

      The Fidelity Crypto Industry and Digital Payments ETF, which launched in April 2022, also tracks the performance of companies involved in the cryptocurrency, blockchain technology and digital payments processing sectors. It has an expense ratio of 0.4 percent, the lowest on this list.

      Of its 49 holdings, 73 percent are headquartered in the United States and 45 percent are involved in the Technology Services sector. Its top holdings include Coinbase Global, MARA Holdings and CleanSpark (NASDAQ:CLSK).

      4. Global X Blockchain (NASDAQ:BKCH)

      Total assets: US$162 million

      Launched in July 2021, the Global X Blockchain ETF is a relatively new blockchain ETF. It tracks the price and yield performance of the Solactive Blockchain Index with a focus on companies in a variety of blockchain segments, such as, but not limited to, digital asset mining, blockchain applications, and blockchain and digital asset transactions.

      At 0.5 percent, this blockchain ETF has the second-lowest expense ratio on the list. Global X Blockchain has 28 holdings, including Coinbase Global, Riot Platforms (NASDAQ:RIOT) and MARA Holdings (NASDAQ:MARA).

      5. First Trust Indxx Innovative Transaction & Process ETF (NASDAQ:LEGR)

      Total assets: US$99 million

      The First Trust Indxx Innovative Transaction & Process ETF also launched in January 2018. First Trust has two types of companies it selects from for its portfolio: companies that employ blockchain and firms that develop it.

      The fund consists of 102 holdings, including companies like NVIDIA (NASDAQ:NVDA), Advanced Micro Devices (NASDAQ:AMD) and Taiwan Semiconductor Manufacturing (NYSE:TSM). It has an expense ratio of 0.65 percent.

      Securities Disclosure: I, Melissa Pistilli, hold no direct investment interest in any company mentioned in this article.

      This post appeared first on investingnews.com

      Adam Rozencwajg, managing partner at Goehring & Rozencwajg, shares his latest thoughts on the gold, silver and uranium markets, also discussing why he’s bullish on platinum.

      In his view, it has ‘all the hallmarks of something we like to get involved with.’

      More broadly, Rozencwajg sees commodities thriving amid a global monetary and trade regime shift.

      Securities Disclosure: I, Charlotte McLeod, hold no direct investment interest in any company mentioned in this article.

      This post appeared first on investingnews.com

      A Malian court has postponed a critical decision on whether to place Barrick Mining’s (TSX:ABX,NYSE:B) flagship Loulo-Gounkoto gold complex under provisional administration

      The move intensifies an already fraught standoff between the Canadian miner and Mali’s military-led government.

      The delay, confirmed to Reuters on Monday (June 2) by the court’s registry office and a lawyer involved in the case, follows the Malian government’s formal request on May 8 for the Bamako Commercial Court to appoint an interim administrator to take over daily operations of the gold complex.

      The court was originally expected to rule on the matter on Monday, after hearing formal opposition from Barrick’s Malian subsidiaries during a preliminary hearing on May 15.

      The dispute centers on Mali’s 2023 mining code, which raised taxes and granted the government a larger stake in mining operations. While the government has since renegotiated terms with other multinational miners, Barrick has resisted transitioning to the new regime, maintaining that its existing agreements remain legally binding.

      Loulo-Gounkoto — one of Mali’s largest gold producers — has been inactive since January, when the government seized approximately 3 metric tons of gold, citing alleged unpaid taxes.

      Since November 2024, Malian authorities have blocked gold exports from the site, with the standoff escalating amid a gold price surge. Gold has jumped 28.5 percent year-to-date, hitting an all-time high of US$3,500.05 per ounce in April.

      Barrick, formerly known as Barrick Gold, has publicly opposed the government’s efforts to take control of its assets, calling the move “without precedent or lawful justification.” In a statement dated May 26, the company said the attempt to install a provisional administrator disregards its rights under Malian law and international agreements.

      “There is no basis — either in law or in practice — for the day-to-day operations at Loulo-Gounkoto to be handed over to a court-appointed interim administrator,” Barrick said. “This action undermines the principles of due process and mutual respect that should govern partnerships between sovereign states and long-term investors.”

      Tensions have been further inflamed by the detention of four Barrick employees since November 2024, and the issuance of an arrest warrant for Chief Executive Mark Bristow in December of the same year.

      According to a court document, the charges include money laundering and financing of terrorism. Barrick has rejected the accusations, but has not elaborated on their specifics.

      Despite the suspension of mining activities, Barrick says it continues to support its workforce, paying wages and maintaining operations on a monthly basis. The company has reiterated that it remains open to resuming talks with the government to secure the release of its detained employees and restart operations.

      In its May 26 release, Barrick notes that in a recent letter to Mali’s minister of economy and finances, the company emphasized its “availability to resume discussions on the terms of a satisfactory agreement,” which would allow for a resolution that serves the interests of employees, the state and all stakeholders.

      Mali, Africa’s third largest gold producer, relies heavily on mining for export earnings and revenue. Barrick, which has operated in Mali for nearly 30 years, has initiated international arbitration under the terms of its mining conventions.

      Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

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      Chinese researchers have unveiled a method of extracting uranium from seawater at a fraction of the previous cost and energy use, positioning the country to potentially secure long-term domestic supply.

      Scientists from Hunan University have developed an advanced electrochemical system that can extract uranium from seawater more efficiently and economically than any method currently in use.

      The innovation, led by Professor Shuangyin Wang and his team, features a novel dual-electrode design using copper at both the positive and negative terminals, allowing uranium ions to be collected simultaneously at both ends.

      The system achieved a 100 percent extraction rate from a synthetic seawater solution within 40 minutes — a remarkable leap from earlier physical adsorption methods, which typically extract less than 10 percent.

      When tested with natural seawater, the device extracted all uranium from East China Sea samples and up to 85 percent from South China Sea water, reaching 100 percent in the latter case with larger electrodes.

      It accomplished these results while consuming over 1,000 times less energy than existing electrochemical systems. The total cost was estimated at US$83 per kilogram of uranium — half the cost of physical adsorption (US$205 per kilogram) and nearly one-fourth that of previous electrochemical approaches (US$360 per kilogram).

      The implications for China’s energy security could be substantial.

      According to the International Energy Agency, China is building more nuclear power plants than any other country, and is expected to surpass the US and EU in installed nuclear capacity by 2030.

      However, much of the uranium needed to fuel this growth is imported. In 2024, China imported 13,000 metric tons of uranium, compared to just 1,700 tonnes mined domestically.

      Given the estimated 4.5 billion metric tons of uranium dissolved in the world’s oceans — over 1,000 times the amount in terrestrial reserves — seawater extraction has long been seen as a tantalizing, but technologically elusive solution.

      Japan led early efforts in the 1980s and 1990s, extracting 1 kilogram of uranium using large-scale marine trials, a milestone that China is now poised to eclipse. The new electrochemical technique builds on recent momentum in China’s marine uranium research. In March of this year, scientists from Lanzhou University’s Frontiers Science Center for Rare Isotopes published a separate study detailing a breakthrough in uranium-vanadium separation, a major technical challenge due to the similar chemical properties of the two elements in seawater.

      The Lanzhou team engineered a metal-organic framework (MOF) material embedded with diphenylethylene molecules that can change pore sizes under ultraviolet light.

      This enabled the MOF to selectively attract uranium ions over vanadium, increasing uranium adsorption capacity to 588 milligrams per gram, and improving uranium-vanadium separation efficiency by 40-fold.

      Their uranium selectivity factor reached 215 — the highest ever reported in natural seawater.

      Both research efforts support China’s national nuclear strategy. In 2019, China National Nuclear partnered with 14 domestic research institutions to establish the Seawater Uranium Extraction Technology Innovation Alliance.

      This government-backed initiative set ambitious milestones: match Japan’s kilogram-level extraction record by 2025, build a metric ton-scale demonstration plant by 2035 and reach continuous industrial production by 2050.

      The alliance’s work is driven by projections from the International Atomic Energy Agency, which forecasts that China’s uranium demand will exceed 40,000 metric tons annually by 2040. Marine extraction, if scaled successfully, could ease long-term supply pressures and reduce geopolitical risk tied to uranium imports.

      Of course, despite promising lab results, transitioning to industrial-scale extraction poses engineering and economic hurdles. For example, scaling up the Hunan system would involve increasing the number and size of electrochemical cells and managing flow rates across larger volumes of seawater.

      If successful, the innovation could revolutionize the global uranium market. By tapping into the ocean’s near-limitless uranium reserves, China could not only meet its own needs, but also shift the geopolitical dynamics of nuclear energy.

      Securities Disclosure: I, Giann Liguid, hold no direct investment interest in any company mentioned in this article.

      This post appeared first on investingnews.com

      Life science companies developing bird flu vaccines and antivirals are gaining attention as the avian influenza subtype H5N1 becomes an increasing concern.

      The United States is in the midst of an H5N1 bird flu outbreak that began in February 2024 and is now threatening the nation’s poultry and cattle industries. With poultry farmers across the US needing to cull their flocks if the virus is detected to prevent it spread, egg prices are shocking shoppers at the country’s grocery stores. Highly pathogenic avian influenza (HPAI) has also spread to cattle and other mammals, including cats.

      Human avian influenza cases have so far been rare during this outbreak in the US, as currently the virus is only spread to humans through exposure to infected animals. As of May 30, 2025, 70 human cases have been detected in the country, and one death has been reported. However, concerns such as the possibility of mutations that could increase the chance of human-to-human transmission are stoking calls for better preparedness and access to bird flu vaccines.

      In this article:

        Is there a vaccine for bird flu?

        There are several bird flu vaccines approved for treating avian influenza in humans, with others under development.

        The Center for Disease Control and Prevention (CDC), a US federal agency under the Department of Health and Human Services, currently holds three different US Food and Drug Administration (FDA) approved vaccines in its strategic national stockpile that can be rapidly updated to address the current strain.

        In the United States, the vaccines would be reserved for workers in the poultry industry if human cases escalate and could be scaled up further if needed in the case of a bird flu pandemic in humans.

        Health Canada has authorized two H5N1 vaccines and laid out a framework for deciding whether to use the vaccines in a non-pandemic context, including increased human cases, human-to-human transmission and increasing severity of outcomes.

        Which companies are producing vaccines for bird flu?

        Some of the biggest companies in the pharmaceutical industry are either producing vaccines for bird flu or actively developing new drug candidates to fight the virus. There are also a number of large-cap and small-cap life science companies with avian influenza vaccines under development.

        Below are nine bird flu vaccine stocks for investor consideration and details of their work on avian influenza. The stocks are listed by market cap based on figures retrieved from TradingView’s stock screener on June 2, 2025.

        1. Pfizer (NYSE:PFE)

        Market cap: US$132.87 billion

        Pfizer is a world-renowned research pharmaceutical company developing drugs in a wide range of areas, including oncology, inflammation and immunology, vaccines, internal medicine and rare diseases. Pfizer and BioNTech created the first FDA-approved mRNA-based COVID-19 vaccine in 2020.

        Pfizer’s mRNA technology could be targeted at producing an avian flu vaccine. In a May 2024 press release, the company stated that it is prepared to address an H5 group influenza pandemic, and reported that in late 2023 it had ‘initiated a randomized Phase 1 study to evaluate the safety, tolerability, and immunogenicity of multiple doses of nucleoside-modified mRNA (modRNA) based pandemic influenza vaccine candidate.’

        2. Sanofi (NASDAQ:SNY)

        Market cap: US$121.34 billion

        Sanofi develops therapeutic products for diabetes and cardiovascular diseases, oncology, immunology, multiple sclerosis, rare diseases, and rare blood disorders. The French multinational pharmaceutical company is also one of the world’s largest manufacturers of vaccines.

        Sanofi’s H5N1 vaccine became the first to be approved by the US FDA back in 2007. Today, it is one of only three US FDA-approved H5N1 vaccines held in the US national stockpile, joined by vaccines from two other pharma firms on this list, CSL Seqirus and GSK.

        In October 2024, the three pharma companies were awarded a combined US$72 million by the US Administration for Strategic Preparedness and Response. The companies will prepare doses of their vaccines to be available if needed, and ‘manufacture additional bulk influenza antigen … from seed stocks that are well matched to circulating strains.’

        3. GSK (NYSE:GSK)

        Market cap: US$83.85 billion

        British multinational biotech company GSK has three main business divisions: pharmaceuticals, consumer healthcare and vaccines. Its vaccine Arexvy is the world’s first respiratory syncytial virus (RSV) vaccine for older adults and is approved for ages 50 and up.

        GSK subsidiary ID Biomedical Corporation of Quebec produces Arepanrix, an H5N1 virus monovalent vaccine, is among the three avian flu vaccines in the US stockpile.

        “GSK’s H5N1 pandemic vaccine can generate some cross-neutralizing antibodies against the current circulating strains and is recognized as an important tool in reducing illness during a possible H5N1 pandemic,” a GSK spokesperson told PharmaVoice. “The vaccine is designed to be updated with the latest circulating strain of interest, as identified by the WHO.”

        In February 2025, the Public Health Agency of Canada announced that through an existing deal with GSK, it has secured an initial supply of 500,000 doses of its avian influenza vaccine.

        GSK also has a mRNA-based H5N1 pre-pandemic vaccine in Phase 2 studies for adults 18 and older. GSK’s mRNA candidate vaccines were previously being developed in partnership with German biopharma CureVac, another company on this list. However, the two restructured the partnership in July 2024, and GSK now has full rights to development, manufacturing and commercialization.

        4. CSL (ASX:CSL,OTCQX:CMXHF)

        Market cap: US$77.54 billion

        Australian multinational biotechnology firm CSL is the parent company of CSL Seqirus, one of the world’s largest influenza vaccine makers. CSL Seqirus has production facilities in the United States, the United Kingdom and Australia.

        CSL Seqirus’ Audenz is among the three avian flu vaccines that make up US stockpiles. The company describes Audenz, which the FDA approved in 2020, as ‘the first-ever adjuvanted, cell-based influenza vaccine designed to protect against influenza A (H5N1) in the event of a pandemic.’

        CSL Seqirus has a manufacturing facility in North Carolina that was built through a public-private partnership with the US government in 2009. According to the company, the facility is the world’s largest cell-based influenza vaccine producer and its highly scalable production method means it’s capable of delivering 150 million influenza vaccine doses within a six-month timeframe as part of an influenza pandemic response.

        5. Moderna (NASDAQ:MRNA)

        Market cap: US$10.37 billion

        Moderna leads the world in the field of mRNA-based medicine from immuno-oncology to infectious diseases, as best demonstrated by its rapid deployment of effective COVID-19 vaccines. The company’s integrated manufacturing plant allows for both clinical and commercial production. Moderna’s mRNA-based bird flu vaccine mRNA-1018 is undergoing a Phase 1/2 study targeting H5 and H7 avian influenza viruses.

        In January 2025, the US Department of Health and Human Services (HHS) under the Biden Administration stated it would award Moderna US$590 million to “accelerate the development of mRNA-based pandemic influenza vaccines and enhance mRNA platform capabilities so that the U.S. is better prepared to respond to other emerging infectious diseases.” This includes its investigational avian flu vaccine.

        However, Reuters reported in late May that the Trump administration has cancelled the contract with Moderna. ‘The cancellation means that the government is discarding what could be one of the most effective and rapid tools to combat an avian influenza outbreak,’ stated Amesh Adalja, senior scholar at the Johns Hopkins Center for Health Security. Moderna stated it will explore alternatives for late-stage development alongside its release of interim Phase 1/2 data.

        6. Novavax (NASDAQ:NVAX)

        Market cap: US$1.13 billion

        American vaccine developer Novavax has a pipeline of early and late-stage vaccine candidates targeting respiratory viruses and other serious infectious diseases. The biotech’s platform is based on its proprietary recombinant protein-based nanoparticle and Matrix-M adjuvant technology.

        Sanofi signed a US$1.2 billion co-exclusive license in May 2024 to co-commercialize Novavax’s adjuvanted COVID-19 vaccine through much of the world.

        Novavax is also conducting pre-clinical studies on a vaccine for H5N1 avian pandemic influenza using its novel approach to immunization. According to the company, ‘Non-human primate studies have shown (its) vaccine candidate can produce protective levels of immunity after a single dose.’

        7. CureVac (NASDAQ:CVAC)

        Market cap: US$1.05 billion

        CureVac is a pioneer in developing mRNA medicines, and the first biotech company in the world “to successfully harness mRNA for medical purposes,” according to its company website. The company’s mRNA-based pipeline is based its on its proprietary RNA technology platform. It focuses on three therapeutic areas: prophylactic vaccines, cancer immunotherapies and molecular therapies.

        CureVac also has an in-house GMP manufacturing facility capable of large-scale production of vaccine doses.

        In 2024, CureVac, in partnership with GSK, began a Phase 1/2 study in the United States on an investigational mRNA-based bird flu vaccine for healthy younger adults aged 18 to 64 and healthy older adults aged 65 to 85 years of age. The vaccine candidate has since been fully licensed to GSK.

        8. Arcturus Therapeutics (NASDAQ:ARCT)

        Market cap: US$345.52 million

        California-based Arcturus Therapeutics is a global commercial mRNA medicines and vaccines company. Its pipeline is focused on the development of infectious respiratory disease vaccines.

        Arcturus is developing an avian flu vaccine based on its STARR self-amplifying mRNA vaccine platform technology. In 2022, the company was awarded US$63.2 million by the US HHS to support development of this vaccine for rapid pandemic influenza response. Phase 1 clinical trials for its H5N1 vaccine candidate began in January and is fully funded by the Biomedical Advanced Research and Development Authority, part of the US HHS.

        Antiviral influenza stocks

        Life science stocks with commercial or clinical-stage antiviral influenza medications are also worth considering for investors interested in bird flu stocks. Here are a few to get you started, listed in alphabetical order.

        Cidara Therapeutics (NASDAQ:CDTX)
        Clinical-stage biotech company Cidara Therapeutics is developing CD388 as a potential universal antiviral for all known strains of both seasonal and pandemic influenza, including H5N1. The antiviral therapy is a drug-Fc conjugate designed as a long-acting neuraminidase inhibitor. The company completed its Phase 2b study earlier this year, with data outputs expected in fall 2025.

        CoCrystal Pharma (NASDAQ:COCP)
        CoCrystal Pharma is a clinical-stage biotech company with a focus on developing antiviral treatments, specifically for influenza, norovirus and COVID-19. The company’s oral influenza PB2 inhibitor CC-42344 is targeted at pandemic and seasonal influenza. Currently in Phase 2a studies, the treatment has shown in vitro activity against the avian influenza A PB2 protein.

        NanoViricides (NYSEAMERICAN:NNVC)
        NanoViricides is a clinical stage nanomedicine technology company. Its lead drug candidate is NV-387, a broad spectrum antiviral therapy that works by mimicking a host-side signature that viruses respond to, meaning it should be effective even as viruses mutate over time. NV-837 is developed to treat respiratory viral infections such as RSV, COVID, Long COVID and H5N1 as well as Mpox, smallpox and measles infections. The company has completed Phase 1 studies.

        Roche (OTCQX:RHHBY,SWX:RO)
        Switzerland-headquartered Roche is one of the world’s largest pharma companies by revenue. Its drug Tamiflu is one of the leading seasonal influenza antiviral treatments, and it can be used to treat avian flu as well. Roche also holds the rights to Japanese pharma company Shionogi & Co.’s (TSE:4507) single-dose influenza antiviral Xofluza outside of Japan and Taiwan. Xofluza is approved in the US for the treatment of seasonal influenza and has shown in vitro activity against avian strains H7N9 and H5N1.

        Traws Pharma (NASDAQ:TRAW)
        Traws Pharma is a clinical stage company leveraging its expertise in small molecule chemistry, artificial intelligence and machine learning in the efficient development of medicines addressing respiratory viral diseases. The company is looking to rapidly progress development of its single-dose H5N1 bird flu antiviral, tivoxavir marboxil, for government stockpiling. In May, Traws received guidance from the FDA on paths for potential approval of the therapy, including the Animal Rule.

        FAQs for bird flu vaccines

        Is there a bird flu vaccine for chickens?

        There are bird flu vaccines for chickens, and farmers in nations such as China, France, Egypt and Mexico use them to inoculate their flocks.

        However, the avian flu vaccines for birds are not commonly used in the United States as they pose logistical challenges and create barriers to trade. In terms of trade, some US trading partners won’t purchase vaccinated chickens as the vaccine can mask an avian flu infection.

        Instead, biosecurity measures such as sanitation and protective wear for workers, and culling of infected flocks are more common practices in the United States.

        In response to the current bird flu outbreak, in mid-February 2025, the US Department of Agriculture conditionally approved a bird flu vaccine for chickens made by Zoetis (NYSE:ZTS), the world’s largest producer of medicine and vaccinations for pets and livestock.

        Is there a bird flu vaccine for cattle?

        There are bird flu vaccines for cattle under development. For example, Medgene, a privately held animal health company based in South Dakota, is developing an H5N1 vaccine for cattle that as of late February 2025 is waiting on imminent conditional approval from the US Department of Agriculture. The company has signed a distribution agreement with global animal health company Elanco Animal Health (NYSE:ELAN) for the vaccine.

        Is there a bird flu vaccine for cats and dogs?

        While both animals can catch avian flu, there are no commercial bird flu vaccines are currently available for cats and dogs. Cats are at higher risk of contracting HPAI bird flu than dogs, but owners of both should take precautionary measures.

        The American Veterinary Medical Association advises cats should be kept indoors. Pet owners should keep outdoor pets, including backyard chicken flocks, away from the wild birds, poultry and cattle.

        Additionally, pet owners must avoid feeding pets raw meat or poultry and unpasteurized milk, and prevent pets from eating dead birds or other animals.

        Securities Disclosure: I, Melissa Pistilli, hold no direct investment interest in any company mentioned in this article.

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